Evidence map›Paper›PMID 26714814›Full record

ArticlePediatric cardiology2016

Elevated Plasma Connective Tissue Growth Factor Levels in Children with Pulmonary Arterial Hypertension Associated with Congenital Heart Disease.

Gang Li, Li Tang, Peng Jia, Jian Zhao, Dong Liu, Bin Liu

Abstract read
PubMed Publisher
In one paragraph

Article in Pediatric cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Gang LiDepartment of Pediatrics, The First Affiliated Hospital of Sichuan Medical University, No. 25 Taiping Street, Luzhou, 646000, Sichuan, China.
Li TangMedical Research Center, The First Affiliated Hospital of Sichuan Medical University, Luzhou, 646000, Sichuan, China.
Peng JiaDepartment of Pediatrics, The First Affiliated Hospital of Sichuan Medical University, No. 25 Taiping Street, Luzhou, 646000, Sichuan, China.
Jian ZhaoDepartment of Pediatrics, The First Affiliated Hospital of Sichuan Medical University, No. 25 Taiping Street, Luzhou, 646000, Sichuan, China.
Dong LiuDepartment of Pediatrics, The First Affiliated Hospital of Sichuan Medical University, No. 25 Taiping Street, Luzhou, 646000, Sichuan, China.
Bin LiuDepartment of Pediatrics, The First Affiliated Hospital of Sichuan Medical University, No. 25 Taiping Street, Luzhou, 646000, Sichuan, China. lblyfy@126.com.
First Affiliated Hospital of Sichuan Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to investigate plasma connective tissue growth factor (CTGF) levels in pulmonary arterial hypertension (PAH) associated with congenital heart disease (CHD) (PAH-CHD) in children and the relationships of CTGF with hemodynamic parameters. Plasma CTGF levels were calculated in 30 children with CHD, 30 children with PAH-CHD and 25 health volunteers, using the subtraction method. Cardiac catheterization was performed to measure clinical hemodynamic parameters. Plasma CTGF levels were significantly higher in PAH-CHD than in those with CHD and health volunteers (p < 0.01). In cyanotic PAH-CHD, plasma CTGF levels were significantly elevated compared with acyanotic PAH-CHD in the same group (p < 0.05). Plasma CTGF levels showed positive correlation with B-type natriuretic peptide (BNP) in PAH-CHD (r = 0.475, p < 0.01), while oxygen saturation was inversely related to plasma CTGF levels (r = -0.436, p < 0.05). There was no correlation between CTGF and hemodynamic parameters. Even though the addition of CTGF to BNP did not significantly increase area under curve for diagnosis of PAH-CHD compared with BNP alone (p > 0.05), it revealed a moderately better specificity, positive predictive value and positive likelihood ratio than BNP alone. Plasma CTGF levels could be a promising diagnostic biomarker for PAH-CHD in children.

Indexed as

HemodynamicsArea Under CurveBiomarkersCardiac CatheterizationCase-Control StudiesChildChild, PreschoolChinaConnective Tissue Growth FactorFemaleHeart Defects, CongenitalHumansHypertension, PulmonaryInfantMaleNatriuretic Peptide, BrainBiomarkersConnective Tissue Growth FactorNatriuretic Peptide, BrainBiomarkerChildrenCongenital heart diseaseConnective tissue growth factorPulmonary arterial hypertension

Identifiers

PMID26714814
OpenAlexW2274413654

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.