ArticleCancer medicine2016
Retrospective analysis of systemic chemotherapy and total parenteral nutrition for the treatment of malignant small bowel obstruction.
Article in Cancer medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03260647 (Risk Stratified Multidisciplinary Ambulatory Management of Malignant Bowel Obstruction), which is not on this map. Cited by 21 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Risk Stratified Multidisciplinary Ambulatory Management of Malignant Bowel Obstruction (MAMBO) Program for Women With Advanced Gynecological Cancers
Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Inoperable malignant bowel obstruction: palliative interventions outcomes - mixed-methods systematic review.BMJ supportive & palliative care · 2024Pooled it
- MASCC multidisciplinary evidence-based recommendations for the management of malignant bowel obstruction in advanced cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Pooled it
- Home parenteral nutrition for people with inoperable malignant bowel obstruction.The Cochrane database of systematic reviews · 2018Pooled it
- A Systematic Review of the Clinical Presentation, Diagnosis, and Treatment of Small Bowel Obstruction.Current gastroenterology reports · 2017Pooled it
- Clinicopathological features and prognosis of metastatic tumors in the small bowel: a large multicenter analysis of the JSCCR database in Japan.Journal of gastroenterology · 2026Article
- Advanced ovarian cancer with malignant bowel obstruction treated with multidisciplinary therapy resulting in long progression-free survival: a case report.BMC women's health · 2025Article
- Bowel obstruction in advanced tubo-ovarian cancer: a retrospective cohort study.Annals of medicine and surgery (2012) · 2023Article
- Malignant Bowel Obstruction Management Over Time: Are We Doing Anything New? A Current Narrative Review.Annals of surgical oncology · 2022Review
- Inoperable Bowel Obstruction in Ovarian Cancer: Prevalence, Impact and Management Challenges.International journal of women's health · 2022Review
- A single-centre ten-year retrospective cohort study of malignant small bowel obstruction.Annals of the Royal College of Surgeons of England · 2021Article
- Chemotherapy After Diagnosis of Malignant Bowel Obstruction is Associated with Superior Survival for Medicare Patients with Advanced Malignancy.Annals of surgical oncology · 2021Article
- The Role of Total Parenteral Nutrition in Patients with Peritoneal Carcinomatosis: A Systematic Review and Meta-Analysis.Cancers · 2021Review
- Survival of Patients with Multi-Level Malignant Bowel Obstruction on Total Parenteral Nutrition at Home.Nutrients · 2021Article
- The Chicago Consensus on Peritoneal Surface Malignancies: Palliative Care Considerations.Annals of surgical oncology · 2020Article
- Surgical and Conservative Management of Malignant Bowel Obstruction: Outcome and Prognostic Factors.Cancer management and research · 2020Article
- Optimizing the Care of Malignant Bowel Obstruction in Patients With Advanced Gynecologic Cancer.Journal of oncology practice · 2019Article
- The role of parenteral nutrition in patients with malignant bowel obstruction.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Review
- Home parenteral nutrition in patients receiving palliative care: a curriculum-based review.Frontline gastroenterology · 2019Review
- Malignant Bowel Obstruction in Advanced Gynecologic Cancers: An Updated Review from a Multidisciplinary Perspective.Obstetrics and gynecology international · 2018Review
- Outcome of decompression using a transnasal ileus tube in malignant adhesive bowel obstruction: A retrospective study.Molecular and clinical oncology · 2017Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Malignant small bowel obstruction (MSBO) that does not resolve with conservative measures frequently leaves few treatment options other than palliative care. This single-institution retrospective study assesses the outcomes of a more aggressive approach-concurrent systemic chemotherapy and total parenteral nutrition (TPN)-in the treatment of MSBO. The MD Anderson pharmacy database was queried to identify patients who received concurrent systemic chemotherapy and TPN between 2005 and 2013. Only patients with MSBO secondary to peritoneal carcinomatosis requiring TPN for ≥8 days were included. Survival and multivariate analyses were performed using the Kaplan-Meier method and Cox proportional hazard models. The study included 82 patients. MSBO resolution was observed in 10 patients. Radiographic assessments showed a response to chemotherapy in 19 patients; 6 of these patients experienced MSBO resolution. Patients spent an average of 38% of their remaining lives hospitalized, and 28% of patients required admission to the intensive care unit. In multivariate modeling, radiographic response to chemotherapy correlated with MSBO resolution (odds ratio [OR] 6.81; 95% confidence interval [CI], 1.68-27.85, P = 0.007). Median overall survival (OS) was 3.1 months, and the 1-year OS rate was 12.6%. Radiographic response to chemotherapy (HR 0.30; 95% CI, 0.16-0.56, P < 0.001), and initiation of new chemotherapy during TPN (HR 0.55; 95% CI, 0.33-0.94, P = 0.026) independently predicted for longer OS. Concurrent treatment with systemic chemotherapy and TPN for persistent MSBO results in low efficacy and a high morbidity and mortality, and thus should not represent a standard approach.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.