Evidence map›Paper›PMID 26714677›Full record

ReviewNeurocritical care2016

Guideline for Reversal of Antithrombotics in Intracranial Hemorrhage: A Statement for Healthcare Professionals from the Neurocritical Care Society and Society of Critical Care Medicine.

Jennifer A Frontera, John J Lewin, Alejandro A Rabinstein, Imo P Aisiku, Anne W Alexandrov, Aaron M Cook, Gregory J del Zoppo, Monisha A Kumar, Ellinor I B Peerschke, Michael F Stiefel and 3 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Neurocritical care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 233 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
233citing papers in PubMed, 13 pooled it
38.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

233 citing papers in PubMed, 13 syntheses or guidelines pooled it, 680 citations in OpenAlex.

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  5. A systematic review and synthesis of global stroke guidelines on behalf of the World Stroke Organization.International journal of stroke : official journal of the International Stroke Society · 2023
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173 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 12 institutions in 4 countries.

Jennifer A FronteraThe Cerebrovascular Center, Neurological Institute, Cleveland Clinic and Case Western Reserve University, 9500 Euclid Ave. S80, Cleveland, OH, 44195, USA. frontej@ccf.org.
John J LewinThe Departments of Pharmacy and Anesthesiology & Critical Care Medicine, The Johns Hopkins Hospital and Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Alejandro A RabinsteinThe Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Imo P AisikuHarvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
Anne W AlexandrovThe University of Tennessee Health Science Center, Memphis, TN, USA.
Aaron M CookDepartment of Pharmacy (UK Healthcare) & Department of Pharmacy Practice & Science (UK College of Pharmacy), University of Kentucky, Lexington, KY, USA.
Gregory J del ZoppoThe Departments of Medicine (Hematology) and Neurology, University of Washington School of Medicine, Seattle, WA, USA.
Monisha A KumarThe Departments of Neurology, Neurosurgery, Anesthesiology & Critical Care, Perelman School of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Ellinor I B PeerschkeThe Department of Laboratory Medicine and Pathology, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical School, New York, NY, USA.
Michael F StiefelThe Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY, USA.
Jeanne S TeitelbaumHôpital du Sacré-Coeur and University of Montreal and Montreal Neurological Institute and McGill University, Montreal, Quebec, Canada.
Katja E WartenbergKlinik für Neurologie, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany.
Cindy L ZerfossThe Neuroscience and Neurosurgery Departments, Centra Lynchburg General Hospital, Lynchburg, VA, USA.
Australian Catholic University · AUBrigham and Women's Hospital · USCentra Health · USCornell University · USHospital of the University of Pennsylvania · USJohns Hopkins University · USMartin Luther University Halle-Wittenberg · DEMayo Clinic in Arizona · USNew York Medical College · USUniversité de Montréal · CAUniversity of Kentucky HealthCare · USUniversity of Washington · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
6 · The paper itself

Abstract

backgroundThe use of antithrombotic agents, including anticoagulants, antiplatelet agents, and thrombolytics has increased over the last decade and is expected to continue to rise. Although antithrombotic-associated intracranial hemorrhage can be devastating, rapid reversal of coagulopathy may help limit hematoma expansion and improve outcomes.

methodsThe Neurocritical Care Society, in conjunction with the Society of Critical Care Medicine, organized an international, multi-institutional committee with expertise in neurocritical care, neurology, neurosurgery, stroke, hematology, hemato-pathology, emergency medicine, pharmacy, nursing, and guideline development to evaluate the literature and develop an evidence-based practice guideline. Formalized literature searches were conducted, and studies meeting the criteria established by the committee were evaluated.

resultsUtilizing the GRADE methodology, the committee developed recommendations for reversal of vitamin K antagonists, direct factor Xa antagonists, direct thrombin inhibitors, unfractionated heparin, low-molecular weight heparin, heparinoids, pentasaccharides, thrombolytics, and antiplatelet agents in the setting of intracranial hemorrhage.

conclusionsThis guideline provides timely, evidence-based reversal strategies to assist practitioners in the care of patients with antithrombotic-associated intracranial hemorrhage.

Indexed as

Critical CareFibrinolytic AgentsHumansIntracranial HemorrhagesNeurologyPractice Guidelines as TopicSocieties, MedicalFibrinolytic AgentsActivated prothrombin complex concentratesAlteplaseAnticoagulantAntidoteAntiplateletAntithromboticaPCCApixabanAspirinClopidogrelCoumadinCryoprecipitateDabigatranDDAVPDesmopressinDirect thrombin inhibitorDTIEdoxabanFactor Xa inhibitorFEIBAFFPFondaparinuxFresh frozen plasmaGRADE criteriaGuidelineHeparinHeparinoidICHIntracerebral hemorrhageIntracranial hemorrhageIntraparenchymal hemorrhageLow-molecular weight heparinPCCPentasaccharidePlasminogen activatorPlateletsProtamineProthrombin complex concentratesRecombinant factor VIIaReversalrFVIIaRivaroxabanrtPASAHSDHSubarachnoid hemorrhageSubdural hematomaThrombolyticTPAVitamin K antagonistVKAWarfarin

Identifiers

PMID26714677
OpenAlexW2214011890

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.