ArticleBMC infectious diseases2015
Whooping cough dynamics in Chile (1932-2010): disease temporal fluctuations across a north-south gradient.
Article in BMC infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Epidemiology of pertussis among adolescents, adults, and older adults in selected countries of Latin American: a systematic review.Human vaccines & immunotherapeutics · 2021Pooled it
- History of whooping cough in Colombia: Endemic infant deaths, outbreaks and epidemicsBiomedica : revista del Instituto Nacional de Salud · 2026Article
- Epidemic malaria dynamics in Ethiopia: the role of self-limiting, poverty, HIV, climate change and human population growth.Malaria journal · 2022Article
- North to south gradient and local waves of influenza in Chile.Scientific reports · 2022Article
- The data used to build the models: Pertussis morbidity and mortality burden considering various Brazilian data sources.Vaccine · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe spatial-temporal dynamics of Bordetella pertussis remains as a highly interesting case in infectious disease epidemiology. Despite large-scale vaccination programs in place for over 50 years around the world, frequent outbreaks are still reported in many countries.
methodsHere, we use annual time series of pertussis incidence from the thirteen different regions of Chile (1952-2010) to study the spatial-temporal dynamics of Pertussis. The period 1975-1995 was characterized by a strong 4 year cycle, while the last two decades of the study period (1990-2010) were characterized by disease resurgence without significant periodic patterns.
resultsDuring the first decades, differences in periodic patterns across regions can be explained by the differences in susceptible recruitment. The observed shift in periodicity from the period 1952-1974 to the period 1975-1995 across regions was relatively well predicted by the susceptible recruitment and population size. However, data on vaccination rates was not taken into account in this study.
conclusionsOur findings highlight how demography and population size have interacted with the immunization program in shaping periodicity along a unique latitudinal gradient. Widespread B. pertussis vaccination appears to lead to longer periodic dynamics, which is line with a reduction in B. pertussis transmission, but our findings indicate that regions characterized by both low birth rate and population size decreased in periodicity following immunization efforts.
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