Evidence map›Paper›PMID 26714633›Full record

ArticleMalaria journal2015

Computer-vision-based technology for fast, accurate and cost effective diagnosis of malaria.

Bina Srivastava, Anupkumar R Anvikar, Susanta K Ghosh, Neelima Mishra, Navin Kumar, Arnon Houri-Yafin, Joseph Joel Pollak, Seth J Salpeter, Neena Valecha

Abstract readEvaluation Study
In one paragraph

Article in Malaria journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Image analysis and machine learning for detecting malaria.Translational research : the journal of laboratory and clinical medicine · 2018
    Review
  7. Review
  8. Diagnostic tools in childhood malaria.Parasites & vectors · 2018
    Review
  9. Evaluation of the Parasight Platform for Malaria Diagnosis.Journal of clinical microbiology · 2017
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bina SrivastavaNational Institute of Malaria Research, Sector 8 Dwarka, New Delhi, 110 077, India. shbira@gmail.com.
Anupkumar R AnvikarNational Institute of Malaria Research, Sector 8 Dwarka, New Delhi, 110 077, India. anvikar@rediffmail.com.
Susanta K GhoshNational Institute of Malaria Research Field Unit, Bengaluru, India. ghoshnimr@gmail.com.
Neelima MishraNational Institute of Malaria Research, Sector 8 Dwarka, New Delhi, 110 077, India. neelima.nimr@gmail.com.
Navin KumarNational Institute of Malaria Research, Sector 8 Dwarka, New Delhi, 110 077, India. navinjh@gmail.com.
Arnon Houri-YafinSight Diagnostics, 1 Agudat Hasport Hapoel, Jerusalem Technology Park, Jerusalem, Israel. arnon@sightdx.com.
Joseph Joel PollakSight Diagnostics, 1 Agudat Hasport Hapoel, Jerusalem Technology Park, Jerusalem, Israel. yossi@sightdx.com.
Seth J SalpeterSight Diagnostics, 1 Agudat Hasport Hapoel, Jerusalem Technology Park, Jerusalem, Israel. seth@sightdx.com.
Neena ValechaNational Institute of Malaria Research, Sector 8 Dwarka, New Delhi, 110 077, India. neenavalecha@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMicroscopy has long been considered to be the gold standard for diagnosis of malaria despite the introduction of newer assays. However, it has many challenges like requirement of trained microscopists and logistic issues. A vision based device that can diagnose malaria, provide speciation and estimate parasitaemia was evaluated.

methodsThe device was evaluated using samples from 431 consented patients, 361 of which were initially screened by RDT and microscopy and later analysed by PCR. It was a prospective, non-randomized, blinded trial. Quantification of parasitaemia was performed by two experienced technicians. Samples were subjected to diagnosis by Sight Dx digital imaging scanning.

resultsThe sensitivity and specificity of the SightDx P1 device for analysed samples were found to be 97.05 and 96.33%, respectively, when compared to PCR. When compared to microscopy, sensitivity and specificity were found to be 94.4 and 95.6%, respectively. The device was able to speciate 73.3% of the PCR Plasmodium falciparum positive samples and 91.4% of PCR Plasmodium vivax positive samples.

conclusionThe ability of the device to detect parasitaemia as compared with microscopy, was within 50% in 71.3% of cases and demonstrated a correlation coefficient of 0.89.

Indexed as

Costs and Cost AnalysisDiagnostic Tests, RoutineHumansImage Processing, Computer-AssistedMalaria, FalciparumMalaria, VivaxOptical ImagingParasitemiaProspective StudiesSensitivity and Specificity

Identifiers

PMID26714633
PMCPMC4696165

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.