Evidence map›Paper›PMID 26714632›Full record

ArticleBMC public health2015

Protocol: a 'One health' two year follow-up, mixed methods study on antibiotic resistance, focusing children under 5 and their environment in rural India.

Cecilia Stålsby Lundborg, Vishal Diwan, Ashish Pathak, Manju R Purohit, Harshada Shah, Megha Sharma, Vijay K Mahadik, Ashok J Tamhankar

Abstract read
In one paragraph

Article in BMC public health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

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  16. Antibiotic-resistantThe Indian journal of medical research · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cecilia Stålsby LundborgDepartment of Public Health Sciences, Global Health - Health Systems and Policy (HSP): Medicines, focusing antibiotics, Karolinska Institutet, 171 77, Stockholm, Sweden. Cecilia.Stalsby.Lundborg@ki.se.
Vishal DiwanDepartment of Public Health Sciences, Global Health - Health Systems and Policy (HSP): Medicines, focusing antibiotics, Karolinska Institutet, 171 77, Stockholm, Sweden. vishaldiwan@hotmail.com.
Ashish PathakDepartment of Public Health Sciences, Global Health - Health Systems and Policy (HSP): Medicines, focusing antibiotics, Karolinska Institutet, 171 77, Stockholm, Sweden. Ashish.Pathak@ki.se.
Manju R PurohitDepartment of Public Health Sciences, Global Health - Health Systems and Policy (HSP): Medicines, focusing antibiotics, Karolinska Institutet, 171 77, Stockholm, Sweden. manjuraj.purohit64@gmail.com.
Harshada ShahDepartment of Microbiology, R.D. Gardi Medical College, Ujjain, India. sharshada1955@yahoo.com.
Megha SharmaDepartment of Public Health Sciences, Global Health - Health Systems and Policy (HSP): Medicines, focusing antibiotics, Karolinska Institutet, 171 77, Stockholm, Sweden. megha.sharma@ki.se.
Vijay K MahadikUjjain Charitable Trust Hospital and Research Centre, Ujjain, India. uctharc@sancharnet.in.
Ashok J TamhankarDepartment of Public Health Sciences, Global Health - Health Systems and Policy (HSP): Medicines, focusing antibiotics, Karolinska Institutet, 171 77, Stockholm, Sweden. ejetee@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAntibiotic resistance has been referred to as 'the greatest malice of the 21st century' and a global action plan was adopted by the World Health Assembly in 2015. There is a wealth of independent studies regarding antibiotics and resistant bacteria in humans, animals and their environment, however, integrated studies are lacking, particularly ones that simultaneously also take into consideration the health related behaviour of participants and healthcare providers. Such, 'One health' studies are difficult to implement, because of the complex teamwork that they entail. This paper describes the protocol of a study that investigates 'One health' issues regarding antibiotic use and antibiotic resistance in children and their environment in Indian villages. METHODS/

designBoth quantitative and qualitative studies are planned for a cohort of children, from 6 villages, and their surrounding environment. Repeated or continues data collection is planned over 2 years for quantitative studies. Qualitative studies will be conducted once. Studies include parents' health seeking behavior for their children (1-3 years of age at the onset), prescribing pattern of formal and informal healthcare providers, analysis of phenotypic antibiotic resistance of Escherichia coli from samples of stool from children and village animals, household drinking water, village source water and waste water, and investigation on molecular mechanisms governing resistance. Analysis of interrelationship of these with each other will also be done as basis for future interventions. Ethics approval has been obtained from the Institutional Ethics Committee R.D. Gardi Medical College, Ujjain, India (No: 2013/07/17-311). DISCUSSION: The findings of the study presented in this protocol will add to our knowledge about the multi-factorial nature of causes governing antibiotic use and antibiotic resistance from a 'One health' perspective. Our study will be the first of its kind addressing antibiotic use and resistance issues related to children in a One-health approach, particularly for rural India.

Indexed as

Drug Resistance, MicrobialAnti-Bacterial AgentsChild, PreschoolDrug UtilizationEnvironmentEscherichia coliFecesFemaleFollow-Up StudiesHumansIndiaInfantInfant, NewbornMalePatient Acceptance of Health CarePhenotypeAnti-Bacterial Agents

Identifiers

PMID26714632
PMCPMC4696104

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.