ReviewMolecular oral microbiology2017
Advances in the microbial etiology and pathogenesis of early childhood caries.
Review in Molecular oral microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 149 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Association Between Early Candida Infection (Oral Thrush) and Severe Early Childhood Caries (S-ECC)
Evaluating Safety and Efficacy of Oral-Spray Bacillus Probiotic (LiveSpo® Smile CARE) in the Prevention and Adjunctive Treatment of Dental Caries in Children
Who cites it
149 citing papers in PubMed, 6 syntheses or guidelines pooled it, 250 citations in OpenAlex.
- Early childhood caries in Africa: prevalence, determinants, and implications for oral health promotion-an umbrella review.Frontiers in oral health · 2026Pooled it
- Association Between Iron Deficiency Anemia and Dental Caries in Children: A Systematic Umbrella Meta-Analysis.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025Pooled it
- Key virulence genes associated withFrontiers in oral health · 2025Pooled it
- Effectiveness of interventions on improving early-life dental care utilization: a systematic review and meta-analysis.Quintessence international (Berlin, Germany : 1985) · 2024Pooled it
- Can oral ADS activity or arginine levels be a caries risk indicator? A systematic review and meta-analysis.Clinical oral investigations · 2018Pooled it
- Candida albicans and Early Childhood Caries: A Systematic Review and Meta-Analysis.Caries research · 2018Pooled it
- Effects of silver diamine fluoride on oral bacteriome and mycobiome: a randomized clinical trial.BMC oral health · 2025Trial
- Relationship between herpesviruses and periodontal disease progression.Journal of clinical periodontology · 2020Trial
- Article
- Longitudinal Association Between Severe Early Childhood Caries and Mandibular Condylar Trabecular Organization: A 3-Year Retrospective Controlled Study.Journal of clinical medicine · 2026Article
- [Age-Related Changes in the Oral Microbiota].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
- HApplied and environmental microbiology · 2026Article
- Salivary Interleukin-6 and Tumor Necrosis Factor-α changes following total oral rehabilitation in children with mild intellectual disability: a prospective interventional study.BMC oral health · 2026Article
- Equity or Two-Tier Care? Guardrails for Silver Diamine Fluoride and Delegated Early Childhood Caries Pathways.Children (Basel, Switzerland) · 2026Article
- Feeding Practices, Prenatal Oral Health Information, and Early Childhood Caries in Toddlers Born Before and During the COVID-19 Pandemic: A Cross-Sectional Study from Hungary.Dentistry journal · 2026Article
- Food-grade Lacticaseibacillus paracasei postbiotics suppress oral Streptococcus mutans biofilm formation and cariogenicity.NPJ science of food · 2026Article
- Multicohort external validation ofFrontiers in cellular and infection microbiology · 2026Article
- Integrated salivary microbiome and metabolome profiling reveals ecological and functional alterations in severe early childhood caries.Journal of translational medicine · 2025Article
- Reproducible 3D bioprinting ofMicrobiology spectrum · 2025Article
- Evaluating microbial regulation as a preventive strategy for radiation-related caries: A review.Head & face medicine · 2025Review
89 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Early childhood caries (ECC) is one of the most prevalent infectious diseases affecting children worldwide. ECC is an aggressive form of dental caries, which, left untreated, can result in rapid and extensive cavitation in teeth (rampant caries) that is painful and costly to treat. Furthermore, it affects mostly children from impoverished backgrounds, and so constitutes a major challenge in public health. The disease is a prime example of the consequences arising from complex, dynamic interactions between microorganisms, host, and diet, leading to the establishment of highly pathogenic (cariogenic) biofilms. To date, there are no effective methods to identify those at risk of developing ECC or to control the disease in affected children. Recent advances in deep-sequencing technologies, novel imaging methods, and (meta)proteomics-metabolomics approaches provide an unparalleled potential to reveal new insights to illuminate our current understanding about the etiology and pathogenesis of the disease. In this concise review, we provide a broader perspective about the etiology and pathogenesis of ECC based on previous and current knowledge on biofilm matrix, microbial diversity, and host-microbe interactions, which could have direct implications for developing new approaches for improved risk assessment and prevention of this devastating and costly childhood health condition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.