ArticlePloS one2015
Titanium Dioxide Nanoparticles Increase Superoxide Anion Production by Acting on NADPH Oxidase.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 47 citations in OpenAlex.
- Assessment of ion release, cytotoxicity, and potential systemic toxicity of titanium dental alloy.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
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- Impact of the Tobacco-Smoking Status on the Phagocyte-Derived Generation of Reactive Oxygen Species: New Modification of the Whole-Blood Chemiluminescence Assay.Luminescence : the journal of biological and chemical luminescence · 2026Article
- Kinetic Effects of Transferrin-Conjugated Gold Nanoparticles on the Antioxidant Glutathione-Thioredoxin Pathway.Antioxidants (Basel, Switzerland) · 2023Article
- Remodeling the hepatic fibrotic microenvironment with emerging nanotherapeutics: a comprehensive review.Journal of nanobiotechnology · 2023Review
- Response of the Endogenous Antioxidant Defense System Induced in RAW 264.7 Macrophages upon Exposure to Dextran-Coated Iron Oxide Nanoparticles.Pharmaceutics · 2023Article
- Toxicity of metal-based nanoparticles: Challenges in the nano era.Frontiers in bioengineering and biotechnology · 2022Review
- Development of coronary dysfunction in adult progeny after maternal engineered nanomaterial inhalation during gestation.Scientific reports · 2021Article
- Detection of Oxidative Stress Induced by Nanomaterials in Cells-The Roles of Reactive Oxygen Species and Glutathione.Molecules (Basel, Switzerland) · 2021Review
- Naringenin mitigates titanium dioxide (TiOInflammation research : official journal of the European Histamine Research Society ... [et al.] · 2018Article
- Evaluation of specific and non-specific immune response of four vaccines for caseous lymphadenitis in sheep challenged.Veterinary world · 2018Article
- Exploring multiple effects of ZnScientific reports · 2018Article
- Integration of metabolomics and transcriptomics in nanotoxicity studies.BMB reports · 2018Article
- Effects of titanium dioxide nanoparticles on human keratinocytes.Drug and chemical toxicology · 2017Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Titanium dioxide (TiO2) anatase nanoparticles (NPs) are metal oxide NPs commercialized for several uses of everyday life. However their toxicity has been poorly investigated. Cellular internalization of NPs has been shown to activate macrophages and neutrophils that contribute to superoxide anion production by the NADPH oxidase complex. Transmission electron micrososcopy images showed that the membrane fractions were close to the NPs while fluorescence indicated an interaction between NPs and cytosolic proteins. Using a cell-free system, we have investigated the influence of TiO2 NPs on the behavior of the NADPH oxidase. In the absence of the classical activator molecules of the enzyme (arachidonic acid) but in the presence of TiO2 NPs, no production of superoxide ions could be detected indicating that TiO2 NPs were unable to activate by themselves the complex. However once the NADPH oxidase was activated (i.e., by arachidonic acid), the rate of superoxide anion production went up to 140% of its value without NPs, this effect being dependent on their concentration. In the presence of TiO2 nanoparticles, the NADPH oxidase produces more superoxide ions, hence induces higher oxidative stress. This hyper-activation and the subsequent increase in ROS production by TiO2 NPs could participate to the oxidative stress development.
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