ArticlePLoS pathogens2015
An Oomycete CRN Effector Reprograms Expression of Plant HSP Genes by Targeting their Promoters.
Article in PLoS pathogens, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 131 citations in OpenAlex.
- Exploiting plant immune "switches" for resistance engineering.Stress biology · 2026Review
- Oomycete plant pathogens: biology, pathogenesis and emerging control strategies.Nature reviews. Microbiology · 2026Review
- Stripe rust fungus subverts wheat phase separation-mediated immunity to promote infection.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Construction of a Normalized Library and Screening of Transcriptional Regulators of theMicroorganisms · 2026Article
- Article
- A catalogue of virulence strategies mediated by phytopathogenic effectors.Fundamental research · 2025Review
- Decoding Plant-Pathogen Interactions: A Comprehensive Exploration of Effector-Plant Transcription Factor Dynamics.Molecular plant pathology · 2025Review
- Correlation Between Effector Gene Expression Targeted by lncRNAs in the Oomycete Fish Pathogen, Saprolegnia parasitica.Marine biotechnology (New York, N.Y.) · 2024Article
- An Isoflavone Synthase Gene inPlants (Basel, Switzerland) · 2024Article
- A conserved oomycete effector RxLR23 triggers plant defense responses by targeting ERD15La to release NbNAC68.Nature communications · 2024Article
- Identification of Phytophthora cinnamomi CRN effectors and their roles in manipulating cell death during Persea americana infection.BMC genomics · 2024Article
- Magnaporthe oryzae effector MoSPAB1 directly activates rice Bsr-d1 expression to facilitate pathogenesis.Nature communications · 2023Article
- Phytophthora sojae effector PsAvh113 associates with the soybean transcription factor GmDPB to inhibit catalase-mediated immunity.Plant biotechnology journal · 2023Article
- Nuclear effectors of plant pathogens: Distinct strategies to be one step ahead.Molecular plant pathology · 2023Review
- The Phytophthora sojae effector PsFYVE1 modulates immunity-related gene expression by targeting host RZ-1A protein.Plant physiology · 2023Article
- Deciphering the underlying immune network of the potato defense response inhibition byFrontiers in plant science · 2023Article
- Progress and Challenges in Elucidating the Functional Role of Effectors in the Soybean-Journal of fungi (Basel, Switzerland) · 2022Review
- The cytosolic iron-sulphur cluster assembly mechanism in grapevine is one target of a virulent Crinkler effector from Plasmopara viticola.Molecular plant pathology · 2022Article
- The secreted ribonuclease T2 protein FoRnt2 contributes to Fusarium oxysporum virulence.Molecular plant pathology · 2022Article
- Evasion of plant immunity by microbial pathogens.Nature reviews. Microbiology · 2022Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oomycete pathogens produce a large number of CRN effectors to manipulate plant immune responses and promote infection. However, their functional mechanisms are largely unknown. Here, we identified a Phytophthora sojae CRN effector PsCRN108 which contains a putative DNA-binding helix-hairpin-helix (HhH) motif and acts in the plant cell nucleus. Silencing of the PsCRN108 gene reduced P. sojae virulence to soybean, while expression of the gene in Nicotiana benthamiana and Arabidopsis thaliana enhanced plant susceptibility to P. capsici. Moreover, PsCRN108 could inhibit expression of HSP genes in A. thaliana, N. benthamiana and soybean. Both the HhH motif and nuclear localization signal of this effector were required for its contribution to virulence and its suppression of HSP gene expression. Furthermore, we found that PsCRN108 targeted HSP promoters in an HSE- and HhH motif-dependent manner. PsCRN108 could inhibit the association of the HSE with the plant heat shock transcription factor AtHsfA1a, which initializes HSP gene expression in response to stress. Therefore, our data support a role for PsCRN108 as a nucleomodulin in down-regulating the expression of plant defense-related genes by directly targeting specific plant promoters.
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