ArticleArthritis care & research2016
Cigarette Smoking and the Risk of Incident Gout in a Prospective Cohort Study.
Article in Arthritis care & research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Single-nucleotide polymorphisms link gout with health-related lifestyle factors in Korean cohorts.PloS one · 2023Pooled it
- Assessing the causal association between smoking behavior and risk of gout using a Mendelian randomization study.Clinical rheumatology · 2018Pooled it
- Association between smoking and gout: a meta-analysis.Clinical rheumatology · 2018Pooled it
- Article
- Association of smoking with serum uric acid levels, hyperuricemia, and gout based on the 7th to 9th Korea National Health and Nutrition Examination Survey: A secondary dataset analysis based on a cross-sectional study.Tobacco induced diseases · 2026Article
- Association between secondhand smoke exposure and hyperuricemia among never smokers: A cross-sectional analysis of NHANES data.Tobacco induced diseases · 2026Article
- Incidence and prevalence of gout in Eastern China from 2011 to 2021: a retrospective population-based study.Annals of medicine · 2025Article
- Network-based machine learning reveals cardiometabolic multimorbidity patterns and modifiable lifestyle factors: a community-focused analysis of NHANES 2015-2018.BMC public health · 2025Article
- Adherence to Life's Essential 8 is associated with lower risk of hyperuricemia among adults in Beijing, China.Frontiers in nutrition · 2025Article
- Lowering the risk of hyperuricemia and gout is associated with ideal cardiovascular health.Journal of health, population, and nutrition · 2024Article
- Advances in Gouty Arthritis Management: Integration of Established Therapies, Emerging Treatments, and Lifestyle Interventions.International journal of molecular sciences · 2024Review
- Dyslipidemia and hyperuricemia: a cross-sectional study of residents in Wuhu, China.BMC endocrine disorders · 2024Article
- A study on the correlation between hyperuricemia and TG/HDL-c ratio in the Naxi ethnic group at high-altitude regions of Yunnan.Frontiers in medicine · 2024Article
- Association between life's essential 8 and hyperuricemia among adults in the United States: insights from NHANES 2005-2018.Frontiers in medicine · 2024Article
- Risk Factors for Hyperuricemia or Gout in Men and Women: The Circulatory Risk in Communities Study (CIRCS).Journal of atherosclerosis and thrombosis · 2023Article
- Investigating the Effect of Cigarette Smoking on Serum Uric Acid Levels in Multiple Sclerosis Patients: A Cross Sectional Study.Brain sciences · 2023Article
- The relationship between education attainment and gout, and the mediating role of modifiable risk factors: a Mendelian randomization study.Frontiers in public health · 2023Article
- Healthy lifestyle counteracts the risk effect of genetic factors on incident gout: a large population-based longitudinal study.BMC medicine · 2022Article
- Association of self-reported snoring and hyperuricaemia: a large cross-sectional study in Chongqing, China.BMJ open · 2022Article
- Monocyte to high-density lipoprotein cholesterol ratio and serum uric acid in Chinese adults: a cross-sectional study.BMC endocrine disorders · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveCigarette smoking is shown to reduce serum urate. However, its impact on risk of gout is unknown. We prospectively examined the relationship between cigarette smoking and gout risk in this Asian cohort.
methodsWe analyzed the data from the Singapore Chinese Health Study, a cohort of 63,257 Chinese ages 45-74 years at recruitment in 1993-1998. Information on cigarette smoking and other lifestyle factors was collected through in-person interviews at recruitment. This analysis included 53,213 participants who took part in either the first followup (1999-2004) and/or the second followup interviews (2006-2010). Cox proportional hazards models were used to assess the relationship between cigarette smoking and gout risk.
resultsA total of 2,244 incident cases of physician-diagnosed gout were identified after a mean followup of 11.1 years. Among men, compared to never smokers, the risk of gout in current smokers was decreased by 27% (hazard ratio [HR] 0.73 [95% confidence interval (95% CI) 0.63-0.84]). This risk reduction was greater in lean male smokers (HR 0.69 [95% CI 0.57-0.83]) than overweight smokers (HR 0.87 [95% CI 0.67-1.13]) (P = 0.09 for interaction). This inverse association with smoking was rapidly attenuated to become null even in former smokers who had recently quit smoking. Conversely, there was no association between smoking and gout risk in women. In a companion cross-sectional study, current smokers had significantly lower levels of serum urate than former and never smokers, and this observation was present in men and not women.
conclusionCurrent smoking is associated with lower risk of gout in men in this Asian cohort.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.