ArticleeLife2015
P1 interneurons promote a persistent internal state that enhances inter-male aggression in Drosophila.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 141 papers.
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Who cites it
141 citing papers in PubMed, 250 citations in OpenAlex.
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- Hunger states modulate aggression via opposing dopamine pathways.Nature communications · 2026Article
- Fertility reversibly modulatesbioRxiv : the preprint server for biology · 2026Article
- Deconstructing a behavioral state: parallel neural integrators control distinct features of an aversive behavioral state inbioRxiv : the preprint server for biology · 2026Article
- Autobehaver: An AI-Based Pipeline for Animal Behavior Analysis.bioRxiv : the preprint server for biology · 2026Article
- Sex-specific behavioral feedback modulates sensorimotor processing and drives flexible social behavior.Nature communications · 2026Article
- Evolutionary basis of male same-sex sexual behavior by multiple pheromone switches in Drosophila.Current biology : CB · 2026Article
- Differential neuronal survival defines a novel axis of sexual dimorphism in the Drosophila brain.Cell genomics · 2026Article
- Sequencing of distinct wing behaviors during Drosophila courtship.Current biology : CB · 2026Article
- Organization and evolution of sex-biased gene expression inbioRxiv : the preprint server for biology · 2026Article
- Neural circuits regulating social dominance implement a strategy predicted by evolutionary game theory.bioRxiv : the preprint server for biology · 2026Article
- Convergence-divergence circuits for multimodal integration of innate and learned opponent valences.Frontiers in systems neuroscience · 2026Article
- Article
- DANCE provides an open-source and low-cost approach to quantify aggression and courtship ineLife · 2025Article
- Evolutionary basis of intermale sexual behavior by multiple pheromone switches inbioRxiv : the preprint server for biology · 2025Article
- Sexual dimorphism in the complete connectome of thebioRxiv : the preprint server for biology · 2025Article
- A neural circuit for context-dependent multimodal signaling in Drosophila.Nature communications · 2025Article
- Neural control of coordinated wing and leg movements during a terrestrial threat display.bioRxiv : the preprint server for biology · 2025Article
81 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
How brains are hardwired to produce aggressive behavior, and how aggression circuits are related to those that mediate courtship, is not well understood. A large-scale screen for aggression-promoting neurons in Drosophila identified several independent hits that enhanced both inter-male aggression and courtship. Genetic intersections revealed that 8-10 P1 interneurons, previously thought to exclusively control male courtship, were sufficient to promote fighting. Optogenetic experiments indicated that P1 activation could promote aggression at a threshold below that required for wing extension. P1 activation in the absence of wing extension triggered persistent aggression via an internal state that could endure for minutes. High-frequency P1 activation promoted wing extension and suppressed aggression during photostimulation, whereas aggression resumed and wing extension was inhibited following photostimulation offset. Thus, P1 neuron activation promotes a latent, internal state that facilitates aggression and courtship, and controls the overt expression of these social behaviors in a threshold-dependent, inverse manner.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.