ArticlePloS one2015
Co-Carriage of blaKPC-2 and blaNDM-1 in Clinical Isolates of Pseudomonas aeruginosa Associated with Hospital Infections from India.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
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- Effect of Force Field Resolution on Membrane Mechanical Response and Mechanoporation Damage under Deformation Simulations.Molecular biotechnology · 2024Article
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- Genomic Characterization of an Extensively Drug-Resistant Extra-Intestinal Pathogenic (ExPEC)Antibiotics (Basel, Switzerland) · 2022Article
- Antimicrobial resistance in patients with suspected urinary tract infections in primary care in Assam, India.JAC-antimicrobial resistance · 2021Article
- Mobile Carbapenemase Genes inFrontiers in microbiology · 2021Review
- Comparison of Different Phenotypic Tests versus PCR in the Detection of Carbapenemase-ProducingInternational journal of microbiology · 2021Article
- Coexistence of two novel resistance plasmids, blaVirulence · 2018Article
- Occurrence of Acquired 16S rRNA Methyltransferase-Mediated Aminoglycoside Resistance in Clinical Isolates of Enterobacteriaceae within a Tertiary Referral Hospital of Northeast India.Antimicrobial agents and chemotherapy · 2017Article
- Transcriptional analysis ofAntimicrobial resistance and infection control · 2017Article
- Carriage ofThe Indian journal of medical research · 2016Article
- Occurrence of co-existing bla VIM-2 and bla NDM-1 in clinical isolates of Pseudomonas aeruginosa from India.Annals of clinical microbiology and antimicrobials · 2016Article
- Detection of carbapenemase-producingJournal of laboratory physiciansArticle
- Prevalence ofJournal of laboratory physiciansArticle
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7 authors.
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Abstract
Global spread of KPC poses to be a serious threat complicating treatment options in hospital settings. The present study investigates the genetic environment of blaKPC-2 among clinical isolates of Pseudomonas aeruginosa from a tertiary referral hospital of India. The study isolates were collected from different wards and clinics of Silchar Medical College and Hospital, India, from 2012-2013. The presence of blaKPC was confirmed by genotypic characterization followed by sequencing. Cloning of the blaKPC-2 gene was performed and the genetic environment of this gene was characterized as well. Transferability of the resistance gene was determined by transformation assay and Southern hybridization. Additionally, restriction mapping was also carried out. Two isolates of P. aeruginosa were found to harbor blaKPC-2, were resistant towards aminoglycosides, quinolone and β-lactam-β-lactamase inhibitor combination. In both the isolates, the resistance determinant was associated with class 1 integron and horizontally transferable. Both the isolates were co-harboring blaNDM-1. The first detection of this integron mediated blaKPC-2 coexisting with blaNDM-1 in P. aeruginosa from India is worrisome, and further investigation is required to track the gene cassette mediated blaKPC-2 in terms of infection control and to prevent the spread of this gene in hospitals as well as in the community.
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