ArticlePLoS computational biology2015
Capabilities and Limitations of Tissue Size Control through Passive Mechanical Forces.
Article in PLoS computational biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Cell-Level Modelling of Homeostasis in Confined Epithelial Monolayers.Journal Of Elasticity · 2025Article
- Choice of friction coefficient deeply affects tissue behaviour in stochastic epithelial vertex models.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Free and Interfacial Boundaries in Individual-Based Models of Multicellular Biological systems.Bulletin of mathematical biology · 2023Article
- Two types of critical cell density for mechanical elimination of abnormal cell clusters from epithelial tissue.PLoS computational biology · 2022Article
- Pinching and pushing: fold formation in the Drosophila dorsal epidermis.Biophysical journal · 2021Article
- Impact of Force Function Formulations on the Numerical Simulation of Centre-Based Models.Bulletin of mathematical biology · 2020Article
- Neuronal differentiation influences progenitor arrangement in the vertebrate neuroepithelium.Development (Cambridge, England) · 2019Article
- Polarized cellular mechano-response system for maintaining radial size in developing epithelial tubes.Development (Cambridge, England) · 2019Article
- Statistics of noisy growth with mechanical feedback in elastic tissues.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Decoding Calcium Signaling Dynamics during Drosophila Wing Disc Development.Biophysical journal · 2019Article
- Tools to reverse-engineer multicellular systems: case studies using the fruit fly.Journal of biological engineering · 2019Review
- Calcium as a signal integrator in developing epithelial tissues.Physical biology · 2018Review
- Simulation of Cell Patterning Triggered by Cell Death and Differential Adhesion in Drosophila Wing.Biophysical journal · 2018Article
- Are Tumor Cell Lineages Solely Shaped by Mechanical Forces?Bulletin of mathematical biology · 2017Article
- Possible roles of mechanical cell elimination intrinsic to growing tissues from the perspective of tissue growth efficiency and homeostasis.PLoS computational biology · 2017Article
- Mechanocellular models of epithelial morphogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Multi-scale computational study of the mechanical regulation of cell mitotic rounding in epithelia.PLoS computational biology · 2017Article
- Comparing individual-based approaches to modelling the self-organization of multicellular tissues.PLoS computational biology · 2017Article
- Robust cell tracking in epithelial tissues through identification of maximum common subgraphs.Journal of the Royal Society, Interface · 2016Article
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Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Embryogenesis is an extraordinarily robust process, exhibiting the ability to control tissue size and repair patterning defects in the face of environmental and genetic perturbations. The size and shape of a developing tissue is a function of the number and size of its constituent cells as well as their geometric packing. How these cellular properties are coordinated at the tissue level to ensure developmental robustness remains a mystery; understanding this process requires studying multiple concurrent processes that make up morphogenesis, including the spatial patterning of cell fates and apoptosis, as well as cell intercalations. In this work, we develop a computational model that aims to understand aspects of the robust pattern repair mechanisms of the Drosophila embryonic epidermal tissues. Size control in this system has previously been shown to rely on the regulation of apoptosis rather than proliferation; however, to date little work has been done to understand the role of cellular mechanics in this process. We employ a vertex model of an embryonic segment to test hypotheses about the emergence of this size control. Comparing the model to previously published data across wild type and genetic perturbations, we show that passive mechanical forces suffice to explain the observed size control in the posterior (P) compartment of a segment. However, observed asymmetries in cell death frequencies across the segment are demonstrated to require patterning of cellular properties in the model. Finally, we show that distinct forms of mechanical regulation in the model may be distinguished by differences in cell shapes in the P compartment, as quantified through experimentally accessible summary statistics, as well as by the tissue recoil after laser ablation experiments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.