ArticlePLoS genetics2015
Dissecting the Genetic Basis of a Complex cis-Regulatory Adaptation.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
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- Existing methods are effective at measuring natural selection on gene expression.Nature ecology & evolution · 2022Article
- Reply to: Existing methods are effective at measuring natural selection on gene expression.Nature ecology & evolution · 2022Article
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- Hearing loss genes reveal patterns of adaptive evolution at the coding and non-coding levels in mammals.BMC biology · 2021Article
- Uncovering Divergence in Gene Expression Regulation in the Adaptation of Yeast to Nitrogen Scarcity.mSystems · 2021Article
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- Turnover of ribosome-associated transcripts from de novo ORFs produces gene-like characteristics available for de novo gene emergence in wild yeast populations.Genome research · 2019Article
- Tissue-Specific cis-Regulatory Divergence Implicates eloF in Inhibiting Interspecies Mating in Drosophila.Current biology : CB · 2018Article
- The genomic landscape of molecular responses to natural drought stress in Panicum hallii.Nature communications · 2018Article
- The genomic basis of environmental adaptation in house mice.PLoS genetics · 2018Article
- The Evolution of Gene Expression in cis and trans.Trends in genetics : TIG · 2018Review
- Design principles for nuclease-deficient CRISPR-based transcriptional regulators.FEMS yeast research · 2018Review
- MitoCPR-A surveillance pathway that protects mitochondria in response to protein import stress.Science (New York, N.Y.) · 2018Article
- High-resolution mapping ofProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Evolutionary biology through the lens of budding yeast comparative genomics.Nature reviews. Genetics · 2017Review
- Cis-regulatory evolution in prokaryotes revealed by interspecific archaeal hybrids.Scientific reports · 2017Article
- Cis-Regulatory Divergence in Gene Expression between Two Thermally Divergent Yeast Species.Genome biology and evolution · 2017Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Although single genes underlying several evolutionary adaptations have been identified, the genetic basis of complex, polygenic adaptations has been far more challenging to pinpoint. Here we report that the budding yeast Saccharomyces paradoxus has recently evolved resistance to citrinin, a naturally occurring mycotoxin. Applying a genome-wide test for selection on cis-regulation, we identified five genes involved in the citrinin response that are constitutively up-regulated in S. paradoxus. Four of these genes are necessary for resistance, and are also sufficient to increase the resistance of a sensitive strain when over-expressed. Moreover, cis-regulatory divergence in the promoters of these genes contributes to resistance, while exacting a cost in the absence of citrinin. Our results demonstrate how the subtle effects of individual regulatory elements can be combined, via natural selection, into a complex adaptation. Our approach can be applied to dissect the genetic basis of polygenic adaptations in a wide range of species.
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