Trial reportArthritis care & research2016
Sensitivity to Change of Patient-Preference Measures for Pain in Patients With Knee Osteoarthritis: Data From Two Trials.
Trial report in Arthritis care & research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Comparative efficacy and safety of exercise modalities in knee osteoarthritis: systematic review and network meta-analysis.BMJ (Clinical research ed.) · 2025Pooled it
- Intra-articular injection of gold micro-particles with hyaluronic acid for painful knee osteoarthritis.BMC musculoskeletal disorders · 2024Trial
- No Added Value of Duloxetine in Patients With Chronic Pain due to Hip or Knee Osteoarthritis: A Cluster-Randomized Trial.Arthritis & rheumatology (Hoboken, N.J.) · 2022Trial
- Associations of foot and ankle characteristics with knee symptoms and function in individuals with patellofemoral osteoarthritis.Journal of foot and ankle research · 2020Trial
- The Efficacy of a Lateral Wedge Insole for Painful Medial Knee Osteoarthritis After Prescreening: A Randomized Clinical Trial.Arthritis & rheumatology (Hoboken, N.J.) · 2019Trial
- Responsiveness of Single versus Composite Measures of Pain in Knee Osteoarthritis.The Journal of rheumatology · 2018Trial
- Longitudinal validation of the Maudsley 3-item visual analogue scale (M3VAS): a new, brief, patient-reported outcome measure of depression.BJPsych open · 2025Article
- Article
- Patient-specific versus off-the-shelf unicompartmental knee arthroplasty during level walking.Journal of experimental orthopaedics · 2025Article
- Long-Term Efficacy of Carboxymethyl-Chitosan in Advanced Knee Osteoarthritis: A Twelve-Month Follow-Up Study on Non-Responders to Hyaluronic Acid.Biomedicines · 2025Article
- Article
- Telehealth mindful exercise for people with knee osteoarthritis: A decentralized feasibility randomized controlled trial.Osteoarthritis and cartilage open · 2024Article
- Clinical Assessment of Osteoarthritis Pain: Contemporary Scenario, Challenges, and Future Perspectives.Pain and therapy · 2024Review
- The efficacy and safety ofHealth science reports · 2024Article
- A Retrospective Study on the Feasibility of Using Low-burden Patient-reported Pain Scores to Track Recovery and Outcomes After Total Joint Replacement.Arthroplasty today · 2024Article
- Exercise therapy for knee osteoarthritis pain: how does it work? A study protocol for a randomised controlled trial.BMJ open · 2024Article
- Cooled radiofrequency ablation of genicular nerves for knee osteoarthritis.The Korean journal of pain · 2024Review
- Reflections from the OARSI 2022 clinical trials symposium: The pain of OA-Deconstruction of pain and patient-reported outcome measures for the benefit of patients and clinical trial design.Osteoarthritis and cartilage · 2023Review
- Review of cooled radiofrequency ablation utilization for the treatment of symptomatic advanced knee arthritis and total knee arthroplasty.Skeletal radiology · 2023Review
- A Novel Mobile App-Based Neuromuscular Electrical Stimulation Therapy for Improvement of Knee Pain, Stiffness, and Function in Knee Osteoarthritis: A Randomized Trial.Arthroplasty today · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveIn osteoarthritis (OA) clinical trials, a pain measure that is most sensitive to change is considered optimal. We compared sensitivity to change of patient-reported pain outcomes, including a patient-preference measure (where the patient nominates an activity that aggravates their pain).
methodsWe used data from 2 trials of patients with confirmed (American College of Rheumatology criteria) knee OA: a trial of brace treatment for patellofemoral OA, and a trial of intraarticular steroids in knee OA. Both trials reported an improvement in pain following treatment. Participants rated pain on a 100-mm visual analog scale (VAS), in the activity that caused them the most knee pain (VASNA ), as well as completing questions on overall knee pain and the Knee Injury and Osteoarthritis Outcome Score (KOOS) questionnaire. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores were also calculated from the KOOS. Standardized changes in each outcome were generated between treatment and control after 6 weeks intervention in the BRACE trial, and 1-2 weeks following intervention in the steroid trial.
resultsThe VASNA produced standardized changes following treatment that were at least as large as other pain outcomes. In the BRACE trial, the between-groups standardized change with the VASNA was -0.63, compared with the KOOS pain subscale change of -0.33, and pain in the last week VAS change of -0.56. In the steroid study, within-group change following treatment in the VASNA was -0.60, compared to the last week VAS change of -0.51, and KOOS pain subscale change of -0.58.
conclusionPain on nominated activity appears to be at least as, and in some cases more, sensitive to change than the KOOS/WOMAC questionnaire.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.