ReviewWorld journal of methodology2015
Immunodiagnosis of human hydatid disease: Where do we stand?
Review in World journal of methodology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 97 citations in OpenAlex.
- Recent advances in clinical and laboratory diagnosis of hydatid cyst: from imaging to recombinant and nanobiosensor-based approaches.Infection · 2026Review
- Bone versus soft tissue hydatid disease: a retrospective comparative cohort study.BMC musculoskeletal disorders · 2026Article
- Laparoscopic management of an infected hepatic hydatid cyst with cystobiliary fistula in a child: a case report.Journal of medical case reports · 2026Article
- Pulmonary Hydatid Cyst Rupture Associated With Albendazole Commencement: Case Report and Literature Review.Case reports in infectious diseases · 2026Article
- Hydatid Cyst in Pregnancy-A Diagnostic and Therapeutic Dilemma: Study Case Report.Journal of clinical medicine · 2025Article
- Update on the Seroepidemiology of Human Cystic Echinococcosis and Associated Risk Factors in Iran: A Systematic Review and Meta-Analysis.Health science reports · 2025Review
- Cardiac Hydatid Cyst in a 34-Year-Old Ethiopian Woman With Heart Failure.JACC. Case reports · 2025Article
- A ten-year evaluation of central nervous system cystic echinococcosis in a highly endemic area of Iran: Molecular epidemiology and clinicopathological characteristics.Parasite epidemiology and control · 2025Article
- Hydatid Cysts of the Psoas Muscle: Insights from the Past Five Years.Life (Basel, Switzerland) · 2024Article
- An unexpected case of an adnexal hydatid cyst in a pregnant woman: a case report.Journal of medical case reports · 2024Article
- Endobronchial Inflammatory Myofibroblastic Tumour Masquerading as a Ruptured Hydatid Cyst.Cureus · 2024Article
- Does the expression of granzyme B participate in inflammation, fibrosis, and fertility of hydatid cysts?Parasitology research · 2023Article
- Synchronous Left Ventricular and Endocranial Mass.Journal of medical cases · 2023Article
- Hydatid Disease of the Liver.Visceral medicine · 2023Review
- Hospital-based retrospective analysis of 224 surgical cases of lung hydatid cyst from southern Iran.Journal of cardiothoracic surgery · 2023Article
- Case Series of Cystic Echinococcosis Over a Twelve-year Period at Sultan Qaboos University Hospital, Oman.Oman medical journal · 2023Article
- Pulmonary Hydatid Cyst in Children and Adults: Diagnosis and Management.The Eurasian journal of medicine · 2022Article
- Turkish HPB Surgery Association consensus report on hepatic cysticTurkish journal of surgery · 2022Article
- Expression and production of protoscolex recombinant P29 protein and its serological evaluation for diagnosis of human hydatidosis.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Article
- Serosurvey of Cystic Echinococcosis and Related Risk Factors for Infection in Fars Province, Southern Iran: A Population-Based Study.BioMed research international · 2022Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cystic echinococcosis (CE) is a zoonotic parasitic infection caused by the larval stage of Echinococcus granulosus. Diagnosis of CE mainly relies on a combination of serological testing along with imaging approaches. A variety of serological methods, mainly based on hydatid cyst fluid, antigen B (AgB) and antigen 5, have been developed and used for immunodiagnosis of CE, yet their performances are not satisfactory. Although utilizing of recombinant or synthetic antigens, improved the performance of serological tests, it has not applicably overcome the problem of low sensitivity and cross reactivity, seen in the diagnosis of CE. Performances of immunodiagnostic tests based on AgB subunits are promising. The 8 kDa subunit of AgB is the most studied antigen in native, synthetic or recombinant form for diagnosis of CE. From the 5 subunits of AgB, antigen B8/1 and B8/2 provided the highest diagnostic sensitivity and specificity. Moreover, detecting of specific antibodies of IgG subclasses has improved the efficacy of immunodiagnostic tests. Among the IgG subclasses, both IgG2 and IgG4 are considered as good markers for diagnosis and IgG4 as a suitable marker for follow up of the patients. In this review an overview of immunodiagnostic methods, related antigens and their performances in the diagnosis of CE are given. The paper highlights pitfall and challenges in the serological diagnosis of CE. Moreover, limitation of currently available immunodiagnostic tests and the most recent development in the designing and application of serological assays for diagnosis of CE in human are addressed.
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