ArticleActa pharmaceutica Sinica. B2015
Prediction of the anti-inflammatory mechanisms of curcumin by module-based protein interaction network analysis.
Article in Acta pharmaceutica Sinica. B, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Synergistic Anti-Cancer Effects of Curcumin and Thymoquinone Against Melanoma.Antioxidants (Basel, Switzerland) · 2024Article
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- Exploring potential genes and pathways related to lung cancer: a graph theoretical analysis.Bioinformation · 2023Article
- Decreased APOC1 expression inhibited cancer progression and was associated with better prognosis and immune microenvironment in esophageal cancer.American journal of cancer research · 2022Article
- Exploring the mechanism of Yixinyin for myocardial infarction by weighted co-expression network and molecular docking.Scientific reports · 2021Article
- Network pharmacology study of Curcuma longa L.: potential target proteins and their functional enrichment analysis.BMC research notes · 2020Article
- Multi-scale supervised clustering-based feature selection for tumor classification and identification of biomarkers and targets on genomic data.BMC genomics · 2020Article
- Mechanism of Astragalus membranaceus in the treatment of laryngeal cancer based on gene co-expression network and molecular docking.Scientific reports · 2020Article
- Identification of G2 and S Phase-Expressed-1 as a Potential Biomarker in Patients with Prostate Cancer.Cancer management and research · 2020Article
- Impact of curcumin on toll-like receptors.Journal of cellular physiology · 2019Review
- Using Network Pharmacology to Explore Potential Treatment Mechanism for Coronary Heart Disease Using Chuanxiong and Jiangxiang Essential Oils in Jingzhi Guanxin Prescriptions.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Inhalation treatment of primary lung cancer using liposomal curcumin dry powder inhalers.Acta pharmaceutica Sinica. B · 2018Article
- In Silico Prediction of the Anti-Depression Mechanism of a Herbal Formula (Tiansi Liquid) Containing Morinda officinalis and Cuscuta chinensis.Molecules (Basel, Switzerland) · 2017Article
- Curcumin inhibits placental inflammation to ameliorate LPS-induced adverse pregnancy outcomes in mice via upregulation of phosphorylated Akt.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2017Article
- Modulatory Mechanism of Polyphenols and Nrf2 Signaling Pathway in LPS Challenged Pregnancy Disorders.Oxidative medicine and cellular longevity · 2017Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Curcumin, the medically active component from Curcuma longa (Turmeric), is widely used to treat inflammatory diseases. Protein interaction network (PIN) analysis was used to predict its mechanisms of molecular action. Targets of curcumin were obtained based on ChEMBL and STITCH databases. Protein-protein interactions (PPIs) were extracted from the String database. The PIN of curcumin was constructed by Cytoscape and the function modules identified by gene ontology (GO) enrichment analysis based on molecular complex detection (MCODE). A PIN of curcumin with 482 nodes and 1688 interactions was constructed, which has scale-free, small world and modular properties. Based on analysis of these function modules, the mechanism of curcumin is proposed. Two modules were found to be intimately associated with inflammation. With function modules analysis, the anti-inflammatory effects of curcumin were related to SMAD, ERG and mediation by the TLR family. TLR9 may be a potential target of curcumin to treat inflammation.
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