ArticleActa pharmaceutica Sinica. B2015
Preliminary investigations into surface molecularly imprinted nanoparticles for Helicobacter pylori eradication.
Article in Acta pharmaceutica Sinica. B, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Epitope-imprinted biomaterials with tailor-made molecular targeting for biomedical applications.Bioactive materials · 2025Review
- Epitope-imprinted polymers: Design principles of synthetic binding partners for natural biomacromolecules.Science advances · 2021Article
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8 authors.
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Abstract
This paper reports investigations into the preparation and characterization of surface molecularly imprinted nanoparticles (SMINs) designed to adhere to Helicobacter pylori (H. pylori). Imprinted nanoparticles were prepared by the inverse microemulsion polymerization method. A fraction of Lpp20, an outer membrane protein of H. pylori known as NQA, was chosen as template and modified with myristic acid to facilitate its localization on the surface of the nanoparticles. The interaction between these SMINs with the template NQA were evaluated using surface plasmon resonance (SPR), change in zeta potential and fluorescence polarization (FP). The results were highly consistent in demonstrating a preferential recognition of the template NQA for SMINs compared with the control nanoparticles. In vitro experiments also indicate that such SMINs are able to adhere to H. pylori and may be useful for H. pylori eradication.
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