Evidence map›Paper›PMID 26713218›Full record

ArticleBiomedical optics express2015

Improved sensitivity to fluorescence for cancer detection in wide-field image-guided neurosurgery.

Michael Jermyn, Yoann Gosselin, Pablo A Valdes, Mira Sibai, Kolbein Kolste, Jeanne Mercier, Leticia Angulo, David W Roberts, Keith D Paulsen, Kevin Petrecca and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Pioneer of Biomedical Optics: Brian C. Wilson.Journal of biomedical optics · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Michael JermynBrain Tumour Research Centre, Montreal Neurological Institute and Hospital, Dept. Neurology and Neurosurgery, McGill University, 3801 University St., Montreal, QC, H3A 2B4, Canada ; Dept. Engineering Physics, Polytechnique Montreal, CP 6079, Succ. Centre-Ville, Montreal, QC, H3C 3A7, Canada.
Yoann GosselinDept. Engineering Physics, Polytechnique Montreal, CP 6079, Succ. Centre-Ville, Montreal, QC, H3C 3A7, Canada.
Pablo A ValdesDept. Neurosurgery, Harvard Medical School, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
Mira SibaiDept. Medical Biophysics, University of Toronto/University Health Network, Toronto, ON, M5G 1L7, Canada.
Kolbein KolsteThaver School of Engineering, Dartmouth College, 14 Engineering Drive, Hanover, NH 03755, USA.
Jeanne MercierDept. Engineering Physics, Polytechnique Montreal, CP 6079, Succ. Centre-Ville, Montreal, QC, H3C 3A7, Canada.
Leticia AnguloDept. Engineering Physics, Polytechnique Montreal, CP 6079, Succ. Centre-Ville, Montreal, QC, H3C 3A7, Canada.
David W RobertsDept. Neurosurgery, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA.
Keith D PaulsenThaver School of Engineering, Dartmouth College, 14 Engineering Drive, Hanover, NH 03755, USA.
Kevin PetreccaBrain Tumour Research Centre, Montreal Neurological Institute and Hospital, Dept. Neurology and Neurosurgery, McGill University, 3801 University St., Montreal, QC, H3A 2B4, Canada.
Olivier DaigleNuvu cameras, 5155 Decelles avenue, Pavillon JA Bombardier, Montreal, QC, H3T 2B1, Canada.
Brian C WilsonDept. Medical Biophysics, University of Toronto/University Health Network, Toronto, ON, M5G 1L7, Canada.
Frederic LeblondDept. Engineering Physics, Polytechnique Montreal, CP 6079, Succ. Centre-Ville, Montreal, QC, H3C 3A7, Canada ; Centre de Recherche du Centre Hospitalier de l'Université de Montréal, rue Saint-Denis, Que, H2X 0A9, Canada.
Dartmouth College · USDartmouth–Hitchcock Medical Center · USMontreal Neurological Institute and Hospital · CA

Funding

Coregistered Fluorescence-Enhanced Resection of Malignant GliomaR01NS052274 · NINDS · DARTMOUTH-HITCHCOCK CLINIC · PI ROBERTS, DAVID W · 2007 to 2018
$4.6M
NINDS NIH HHS R01 NS052274
6 · The paper itself

Abstract

In glioma surgery, Protoporphyrin IX (PpIX) fluorescence may identify residual tumor that could be resected while minimizing damage to normal brain. We demonstrate that improved sensitivity for wide-field spectroscopic fluorescence imaging is achieved with minimal disruption to the neurosurgical workflow using an electron-multiplying charge-coupled device (EMCCD) relative to a state-of-the-art CMOS system. In phantom experiments the EMCCD system can detect at least two orders-of-magnitude lower PpIX. Ex vivo tissue imaging on a rat glioma model demonstrates improved fluorescence contrast compared with neurosurgical fluorescence microscope technology, and the fluorescence detection is confirmed with measurements from a clinically-validated spectroscopic probe. Greater PpIX sensitivity in wide-field fluorescence imaging may improve the residual tumor detection during surgery with consequent impact on survival.

Indexed as

(170.3890) Medical optics instrumentation(170.6280) Spectroscopy, fluorescence and luminescence

Identifiers

PMID26713218
PMCPMC4679278
OpenAlexW2235145462

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.