Evidence map›Paper›PMID 26713210›Full record

ArticleBiomedical optics express2015

Calibration and optimization of 3D digital breast tomosynthesis guided near infrared spectral tomography.

Kelly E Michaelsen, Venkataramanan Krishnaswamy, Linxi Shi, Srinivasan Vedantham, Steven P Poplack, Andrew Karellas, Brian W Pogue, Keith D Paulsen

Abstract read
In one paragraph

Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Emerging Breast Imaging Technologies on the Horizon.Seminars in ultrasound, CT, and MR · 2018
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kelly E MichaelsenThayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.
Venkataramanan KrishnaswamyThayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.
Linxi ShiDepartment of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA ; Currently at School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
Srinivasan VedanthamDepartment of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Steven P PoplackThayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA ; Currently at Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Andrew KarellasDepartment of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Brian W PogueThayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.
Keith D PaulsenThayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.

Funding

Optical Imaging Fused with Tomosynthesis for Improved Breast CancerR01CA139449 · NCI · DARTMOUTH COLLEGE · PI PAULSEN, KEITH D. · 2009 to 2013
$2.9M
Combined Breast Tomosynthesis and Near Infrared Spectroscopy for Cancer DetectionF30CA168079 · NCI · DARTMOUTH COLLEGE · PI MICHAELSEN, KELLY · 2013 to 2016
$150k
NCI NIH HHS F30 CA168079NCI NIH HHS R01 CA139449
6 · The paper itself

Abstract

Calibration of a three-dimensional multimodal digital breast tomosynthesis (DBT) x-ray and non-fiber based near infrared spectral tomography (NIRST) system is challenging but essential for clinical studies. Phantom imaging results yielded linear contrast recovery of total hemoglobin (HbT) concentration for cylindrical inclusions of 15 mm, 10 mm and 7 mm with a 3.5% decrease in the HbT estimate for each 1 cm increase in inclusion depth. A clinical exam of a patient's breast containing both benign and malignant lesions was successfully imaged, with greater HbT was found in the malignancy relative to the benign abnormality and fibroglandular regions (11 μM vs. 9.5 μM). Tools developed improved imaging system characterization and optimization of signal quality, which will ultimately improve patient selection and subsequent clinical trial results.

Indexed as

(120.3890) Medical optics instrumentation(170.0110) Imaging systems(170.3830) Mammography

Identifiers

PMID26713210
PMCPMC4679270

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.