ArticleBiomedical optics express2015
Quantifying Gleason scores with photoacoustic spectral analysis: feasibility study with human tissues.
Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Raman spectroscopic signatures of prostate cancer progression: correlation with gleason score.Molecular and cellular biochemistry · 2026Article
- Photoacoustic clinical applications: Musculoskeletal and abdominal imaging.Zeitschrift fur medizinische Physik · 2023Review
- Fabrication of a translational photoacoustic needle sensing probe for interstitial photoacoustic spectral analysis.Photoacoustics · 2023Article
- Identification of different types of tumors based on photoacoustic spectral analysis: preclinical feasibility studies on skin tumors.Journal of biomedical optics · 2023Article
- Molecular breast cancer subtype identification using photoacoustic spectral analysis and machine learning at the biomacromolecular level.Photoacoustics · 2023Article
- Article
- Quick identification of prostate cancer by wavelet transform-based photoacoustic power spectrum analysis.Photoacoustics · 2022Article
- Prostate cancer identification via photoacoustic spectroscopy and machine learning.Photoacoustics · 2021Article
- Characterizing the aggressiveness of prostate cancer using an all-optical needle photoacoustic sensing probe: feasibility study.Biomedical optics express · 2021Article
- Photoacoustic power azimuth spectrum for microvascular evaluation.Photoacoustics · 2021Article
- Photoacoustic spectral analysis at ultraviolet wavelengths for characterizing the Gleason grades of prostate cancer.Optics letters · 2020Article
- Ambient ionization mass spectrometry imaging for disease diagnosis: Excitements and challenges.Journal of biosciences · 2018Review
- Interstitial assessment of aggressive prostate cancer by physio-chemical photoacoustics: An ex vivo study with intact human prostates.Medical physics · 2018Article
- Frequency Domain Analysis of Multiwavelength Photoacoustic Signals for Differentiating Among Malignant, Benign, and Normal Thyroids in an Ex Vivo Study With Human Thyroids.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2017Article
- Diagnosis of prostate cancer by desorption electrospray ionization mass spectrometric imaging of small metabolites and lipids.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Interstitial photoacoustic spectral analysis: instrumentation and validation.Biomedical optics express · 2017Article
- Characterizing cellular morphology by photoacoustic spectrum analysis with an ultra-broadband optical ultrasonic detector.Optics express · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Gleason score is a highly prognostic factor for prostate cancer describing the microscopic architecture of the tumor tissue. The standard procedure for evaluating Gleason scores, namely biopsy, is to remove prostate tissue for observation under microscope. Currently, biopsies are guided by transrectal ultrasound (TRUS). Due to the low sensitivity of TRUS to prostate cancer (PCa), non-guided and saturated biopsies are frequently employed, unavoidably causing pain, damage to the normal prostate tissues and other complications. More importantly, due to the limited number of biopsy cores, current procedure could either miss early stage small tumors or undersample aggressive cancers. Photoacoustic (PA) measurement has the unique capability of evaluating tissue microscopic architecture information at ultrasonic resolution. By frequency domain analysis of the broadband PA signal, namely PA spectral analysis (PASA), the microscopic architecture within the assessed tissue can be quantified. This study investigates the feasibility of evaluating Gleason scores by PASA. Simulations with the classic Gleason patterns and experiment measurements from human PCa tissues have demonstrated strong correlation between the PASA parameters and the Gleason scores.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.