Evidence map›Paper›PMID 26713076›Full record

ReviewExperimental neurobiology2015

Characteristics of Brains in Autism Spectrum Disorder: Structure, Function and Connectivity across the Lifespan.

Sungji Ha, In-Jung Sohn, Namwook Kim, Hyeon Jeong Sim, Keun-Ah Cheon

Registry-linked trialAbstract readReview
In one paragraph

Review in Experimental neurobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05499910 (Training in Neuro Strengths-Based Approach to Autism), which is not on this map. Cited by 129 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05499910 nacompletednot on this mapstarted 2022, after this paper: background citation

Training in Neuro Strengths-Based Approach to Autism

TypeinterventionalSponsorBaio EnterprisesRan2022 to 2023Enrolled16ConditionsAutism Spectrum DisorderArmsNSBAA
3 · Its place in the literature

Who cites it

129 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Auditory Sensitivity in Autism: A Systematic Review of Mismatch Negativity and Mismatch Field Responses.Autism research : official journal of the International Society for Autism Research · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Maternal Dietary Factors and the Risk of Autism Spectrum Disorders: A Systematic Review of Existing Evidence.Autism research : official journal of the International Society for Autism Research · 2020
    Pooled it
  5. Article
  6. Altered Brain Structure in an ATRX-Deficient Mouse Model of Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2026
    Article
  7. Article
  8. A functional system-informed graph neural network framework to quantify interpretable brain dysfunction in ASD.Neural networks : the official journal of the International Neural Network Society · 2026
    Article
  9. Article
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  19. Article
  20. The Ambiguous Role of Growth Factors in Autism: What Do We Really Know?International journal of molecular sciences · 2025
    Review

69 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sungji HaDepartment of Psychiatry, Institute of Behavioral Science in Medicine and Yonsei Autism Laboratory, Yonsei University College of Medicine, Seoul 03722, Korea.
In-Jung SohnDepartment of Psychiatry, Institute of Behavioral Science in Medicine and Yonsei Autism Laboratory, Yonsei University College of Medicine, Seoul 03722, Korea. ; Division of Child and Adolescent Psychiatry, Severance Children's Hospital, Yonsei University College of Medicine, Seoul 03722, Korea.
Namwook KimDepartment of Psychiatry, Institute of Behavioral Science in Medicine and Yonsei Autism Laboratory, Yonsei University College of Medicine, Seoul 03722, Korea. ; Division of Child and Adolescent Psychiatry, Severance Children's Hospital, Yonsei University College of Medicine, Seoul 03722, Korea.
Hyeon Jeong SimDepartment of Psychiatry, Institute of Behavioral Science in Medicine and Yonsei Autism Laboratory, Yonsei University College of Medicine, Seoul 03722, Korea.
Keun-Ah CheonDepartment of Psychiatry, Institute of Behavioral Science in Medicine and Yonsei Autism Laboratory, Yonsei University College of Medicine, Seoul 03722, Korea. ; Division of Child and Adolescent Psychiatry, Severance Children's Hospital, Yonsei University College of Medicine, Seoul 03722, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a highly prevalent neurodevelopmental disorder characterized by impaired social communication and restricted and repetitive behaviors (RRBs). Over the past decade, neuroimaging studies have provided considerable insights underlying neurobiological mechanisms of ASD. In this review, we introduce recent findings from brain imaging studies to characterize the brains of ASD across the human lifespan. Results of structural Magnetic Resonance Imaging (MRI) studies dealing with total brain volume, regional brain structure and cortical area are summarized. Using task-based functional MRI (fMRI), many studies have shown dysfunctional activation in critical areas of social communication and RRBs. We also describe several data to show abnormal connectivity in the ASD brains. Finally, we suggest the possible strategies to study ASD brains in the future.

Indexed as

Autism spectrum disorder (ASD)Diffusion tensor image (DTI)Functional MRI (fMRI)Magnetic resonance image (MRI)Neuroimaging

Identifiers

PMID26713076
PMCPMC4688328

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.