Evidence map›Paper›PMID 26713059›Full record

SynthesisJournal of Korean medical science2015

Early Caffeine Use in Very Low Birth Weight Infants and Neonatal Outcomes: A Systematic Review and Meta-Analysis.

Hye Won Park, Gina Lim, Sung-Hoon Chung, Sochung Chung, Kyo Sun Kim, Soo-Nyung Kim

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of Korean medical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 4 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 4 syntheses or guidelines pooled it, 66 citations in OpenAlex.

  1. Administration time of caffeine in preterm infants: systematic review and meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Hye Won ParkDepartment of Pediatrics, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.ORCID 0000-0002-2669-3621
Gina LimDepartment of Pediatrics, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.ORCID 0000-0001-8996-2713
Sung-Hoon ChungDepartment of Pediatrics, Kyung Hee University School of Medicine, Seoul, Korea.ORCID 0000-0002-0352-9722
Sochung ChungDepartment of Pediatrics, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.ORCID 0000-0002-7655-2691
Kyo Sun KimDepartment of Pediatrics, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.ORCID 0000-0001-9322-6508
Soo-Nyung KimDepartment of Obstetrics and Gynecology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.ORCID 0000-0003-4319-336X
Konkuk University Medical Center · KRKyung Hee University · KRUlsan College · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of caffeine citrate for treatment of apnea in very low birth weight infants showed short-term and long-term benefits. A systematic review and meta-analysis of the literature was undertaken to document the effect providing caffeine early (0-2 days of life) compared to providing caffeine late (≥3 days of life) in very low birth weight infants on several neonatal outcomes, including bronchopulmonary dysplasia (BPD). We searched MEDLINE, the EMBASE database, the Cochrane Library, and KoreaMed for this meta-analysis. The quality of the included studies was assessed using the Newcastle-Ottawa Scale and Jadad's scale. Studies were included if they examined the effect of the early use of caffeine compared with the late use of caffeine. Two reviewers screened the candidate articles and extracted the data from the full-text of all of the included studies. We included a total of 59,136 participants (range 58,997-59,136; variable in one study) from a total of 5 studies. The risk of death (odds ratio [OR], 0.902; 95% confidence interval [CI], 0.828 to 0.983; P=0.019), bronchopulmonary dysplasia (BPD) (OR, 0.507; 95% CI, 0.396 to 0.648; P<0.001), and BPD or death (OR, 0.526; 95% CI, 0.384 to 0.719; P<0.001) were lower in the early caffeine group. Early caffeine use was not associated with a risk of necrotizing enterocolitis (NEC) and NEC requiring surgery. This meta-analysis suggests that early caffeine use has beneficial effects on neonatal outcomes, including mortality and BPD, without increasing the risk of NEC.

Indexed as

ApneaBronchopulmonary DysplasiaCaffeineCitratesEnterocolitis, NecrotizingHumansInfantInfant MortalityInfant, NewbornInfant, Very Low Birth WeightRisk FactorsTreatment OutcomeCaffeinecaffeine citrateCitratesBronchopulmonary DysplasiaCaffeineInfant, NewbornOutcomeVery Low Birth Weight

Identifiers

PMID26713059
PMCPMC4689828
OpenAlexW2210108998

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.