Evidence map›Paper›PMID 26712950›Full record

ArticleThe Journal of infectious diseases2016

Role of the Gut Microbiota of Children in Diarrhea Due to the Protozoan Parasite Entamoeba histolytica.

Carol A Gilchrist, Sarah E Petri, Brittany N Schneider, Daniel J Reichman, Nona Jiang, Sharmin Begum, Koji Watanabe, Caroline S Jansen, K Pamela Elliott, Stacey L Burgess and 5 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 1 synthesis or guideline pooled it, 121 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
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  15. Review
  16. The curious case ofGut microbes · 2023
    Review
  17. Article
  18. Molecular-Genotyping Detection ofArchives of Razi Institute · 2023
    Article
  19. Article
  20. Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Carol A GilchristDepartment of Medicine.
Sarah E PetriDepartment of Medicine.
Brittany N SchneiderDepartment of Medicine.
Daniel J ReichmanDepartment of Medicine.
Nona JiangDepartment of Medicine.
Sharmin BegumInternational Centre for Diarrhoeal Diseases Research, Dhaka, Bangladesh.
Koji WatanabeDepartment of Medicine.
Caroline S JansenDepartment of Medicine.
K Pamela ElliottDepartment of Medicine.
Stacey L BurgessDepartment of Medicine.
Jennie Z MaDivision of Biostatistics, Department of Public Health Sciences School of Medicine, University of Virginia, Charlottesville.
Masud AlamInternational Centre for Diarrhoeal Diseases Research, Dhaka, Bangladesh.
Mamun KabirInternational Centre for Diarrhoeal Diseases Research, Dhaka, Bangladesh.
Rashidul HaqueInternational Centre for Diarrhoeal Diseases Research, Dhaka, Bangladesh.
William A PetriDepartment of Medicine.
International Centre for Diarrhoeal Disease Research · BDUniversity of Virginia · US

Funding

INTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007496 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Michael G. Brown, Coleen A McNamara · 1995 to 2026
$10.2M
FIELD STUDIES OF IMMUNITY TO AMEBIASIS IN BANGLADESHR01AI043596 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI CAROL A GILCHRIST, William A Petri · 1998 to 2026
$7.7M
Development of an E. histolytica Multilocus Genotyping SystemR21AI103536 · NIAID · UNIVERSITY OF VIRGINIA · PI GILCHRIST, CAROL A · 2013 to 2014
$422k
NIAID NIH HHS AI043596NIAID NIH HHS AI103536-01NIAID NIH HHS R01 AI043596NIAID NIH HHS R21 AI103536NIAID NIH HHS T32 AI007496
6 · The paper itself

Abstract

backgroundAn estimated 1 million children die each year before their fifth birthday from diarrhea. Previous population-based surveys of pediatric diarrheal diseases have identified the protozoan parasite Entamoeba histolytica, the etiological agent of amebiasis, as one of the causes of moderate-to-severe diarrhea in sub-Saharan Africa and South Asia.

methodsWe prospectively studied the natural history of E. histolytica colonization and diarrhea among infants in an urban slum of Dhaka, Bangladesh.

resultsApproximately 80% of children were infected with E. histolytica by the age of 2 years. Fecal anti-galactose/N-acetylgalactosamine lectin immunoglobulin A was associated with protection from reinfection, while a high parasite burden and expansion of the Prevotella copri level was associated with diarrhea.

conclusionsE. histolytica infection was prevalent in this population, with most infections asymptomatic and diarrhea associated with both the amount of parasite and the composition of the microbiota.

Indexed as

Gastrointestinal MicrobiomeAnimalsAntibodies, ProtozoanBangladeshCohort StudiesDiarrhea, InfantileEntamoeba histolyticaEntamoebiasisFecesFemaleFollow-Up StudiesHumansImmunoglobulin AInfantLectinsLongitudinal StudiesAntibodies, ProtozoanImmunoglobulin ALectinsamebiasisEntamoeba histolyticaenvironmental enteropathyIgAPrevotella copri

Identifiers

PMID26712950
PMCPMC4837909
OpenAlexW2254755113

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.