ArticleMarine drugs2015
The Structure-Activity Relationship between Marine Algae Polysaccharides and Anti-Complement Activity.
Article in Marine drugs, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Marine Food Polysaccharides: Representative Structural Features, Immunomodulatory Effects, and Food Applications.Marine drugs · 2026Review
- Optimization and chemical modification of exopolysaccharides from lactic acid bacteria: multi-functional health-promoting properties and structure-activity relationship.Archives of microbiology · 2026Article
- Biochemical Composition and Alkaline Extraction Optimization of Soluble Bioactive Compounds from the Green AlgaeMarine drugs · 2025Article
- Bioactive carbohydrate polymers from marine sources as potent nutraceuticals in modulating obesity: a review.Food science and biotechnology · 2024Review
- Fucoidans inhibited tau interaction and cellular uptake.Carbohydrate polymers · 2023Article
- Sulfated Galactofucans: An Outstanding Class of Fucoidans with Promising Bioactivities.Marine drugs · 2022Review
- Interactions of marine sulfated glycans with antithrombin and platelet factor 4.Frontiers in molecular biosciences · 2022Article
- Molecular Mechanism of Anti-Inflammatory Activities of a Novel Sulfated Galactofucan fromMarine drugs · 2021Article
- The structure-activity relationship of the interactions of SARS-CoV-2 spike glycoproteins with glucuronomannan and sulfated galactofucan from Saccharina japonica.International journal of biological macromolecules · 2020Article
- Structural characteristics and anti-complement activities of polysaccharides from Sargassum hemiphyllum.Glycoconjugate journal · 2020Article
- Interactions of fibroblast growth factors with sulfated galactofucan from Saccharina japonica.International journal of biological macromolecules · 2020Article
- Article
- Structural Features of Sulfated Glucuronomannan Oligosaccharides and Their Antioxidant Activity.Marine drugs · 2018Article
- Water-soluble polysaccharides from Ulva intestinalis: Molecular properties, structural elucidation and immunomodulatory activities.Journal of food and drug analysis · 2018Article
- Genome Mining of the Marine ActinomyceteFrontiers in microbiology · 2018Article
- Melanoma and brown seaweed: an integrative hypothesis.Journal of applied phycology · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, 33 different polysaccharides were prepared to investigate the structure-activity relationships between the polysaccharides, mainly from marine algae, and anti-complement activity in the classical pathway. Factors considered included extraction methods, fractionations, molecular weight, molar ratio of galactose to fucose, sulfate, uronic acid (UA) content, linkage, branching, and the type of monosaccharide. It was shown that the larger the molecular weights, the better the activities. The molar ratio of galactose (Gal) to fucose (Fuc) was a positive factor at a concentration lower than 10 µg/mL, while it had no effect at a concentration more than 10 µg/mL. In addition, sulfate was necessary; however, the sulfate content, the sulfate pattern, linkage and branching had no effect at a concentration of more than 10 µg/mL. Moreover, the type of monosaccharide had no effect. Laminaran and UA fractions had no activity; however, they could reduce the activity by decreasing the effective concentration of the active composition when they were mixed with the active compositions. The effect of the extraction methods could not be determined. Finally, it was observed that sulfated galactofucan showed good anti-complement activity after separation.
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