ArticleMolecules (Basel, Switzerland)2015
Application of Ultra-High-Performance Liquid Chromatography Coupled with LTQ-Orbitrap Mass Spectrometry for the Qualitative and Quantitative Analysis of Polygonum multiflorum Thumb. and Its Processed Products.
Article in Molecules (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Study on the differential hepatotoxicity of raw polygonum multiflorum and polygonum multiflorum praeparata and its mechanism.BMC complementary medicine and therapies · 2024Article
- Processing ofFrontiers in pharmacology · 2024Article
- On-line identification of the chemical constituents of Polygoni Multiflori Radix by UHPLC-Q-ToF MS/MS.Frontiers in chemistry · 2023Article
- Mitochondrial-Respiration-Improving Effects of Three Different Gardeniae Fructus Preparations and Their Components.ACS omega · 2021Article
- Screening of Quality Markers During the Processing ofFrontiers in pharmacology · 2021Article
- The Potential Antioxidant Activity and Characterization of Bioactive Compounds ofBioMed research international · 2021Article
- Phytochemical Analysis, Anti-inflammatory, and Antioxidant Activities ofBioMed research international · 2020Article
- Metabolomics Approach for Discrimination and Quality Control of Natural and CommercialInternational journal of analytical chemistry · 2020Article
- Rapid Analysis of the Chemical Compositions inMolecules (Basel, Switzerland) · 2019Article
- A proposed protocol based on integrative metabonomics analysis for the rapid detection and mechanistic understanding of sulfur fumigation of Chinese herbal medicines.RSC advances · 2019Article
- Profile of Bioactive Compounds in the Morphological Parts of WildMolecules (Basel, Switzerland) · 2019Article
- Phytochemical Diversity in Rhizomes of ThreeMolecules (Basel, Switzerland) · 2019Article
- Influence Factors on the Hepatotoxicity ofEvidence-based complementary and alternative medicine : eCAM · 2019Review
- Qualitative and Quantitative Analysis for the Chemical Constituents ofEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Identification and Differentiation ofJournal of analytical methods in chemistry · 2019Article
- Review
- Integrating Targeted and Untargeted Metabolomics to Investigate the Processing Chemistry of Polygoni Multiflori Radix.Frontiers in pharmacology · 2018Article
- Chemical Analysis and Multi-Component Determination in Chinese Medicine Preparation Bupi Yishen Formula Using Ultra-High Performance Liquid Chromatography With Linear Ion Trap-Orbitrap Mass Spectrometry and Triple-Quadrupole Tandem Mass Spectrometry.Frontiers in pharmacology · 2018Article
- Simultaneous Qualitation and Quantitation of Chlorogenic Acids in Kuding Tea Using Ultra-High-Performance Liquid Chromatography-Diode Array Detection Coupled with Linear Ion Trap-Orbitrap Mass Spectrometer.Molecules (Basel, Switzerland) · 2016Article
- Enhanced Production of Anthraquinones and Phenolic Compounds and Biological Activities in the Cell Suspension Cultures of Polygonum multiflorum.International journal of molecular sciences · 2016Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to quickly and simultaneously obtain the chemical profiles and control the quality of the root of Polygonum multiflorum Thumb. and its processed form, a rapid qualitative and quantitative method, using ultra-high-performance liquid chromatography coupled with electrospray ionization-linear ion trap-Orbitrap hybrid mass spectrometry (UHPLC-LTQ-Orbitrap MS(n)) has been developed. The analysis was performed within 10 min on an AcQuity UPLC™ BEH C18 column with a gradient elution of 0.1% formic acid-acetonitrile at flow rate of 400 μL/min. According to the fragmentation mechanism and high resolution MS(n) data, a diagnostic ion searching strategy was used for rapid and tentative identification of main phenolic components and 23 compounds were simultaneously identified or tentatively characterized. The difference in chemical profiles between P. multiflorum and its processed preparation were observed by comparing the ions abundances of main constituents in the MS spectra and significant changes of eight metabolite biomarkers were detected in the P. multiflorum samples and their preparations. In addition, four of the representative phenols, namely gallic acid, trans-2,3,5,4'-tetra-hydroxystilbene-2-O-β-d-glucopyranoside, emodin and emodin-8-O-β-d-glucopyranoside were quantified by the validated UHPLC-MS/MS method. These phenols are considered to be major bioactive constituents in P. multiflorum, and are generally regarded as the index for quality assessment of this herb. The method was successfully used to quantify 10 batches of P. multiflorum and 10 batches of processed P. multiflorum. The results demonstrated that the method is simple, rapid, and suitable for the discrimination and quality control of this traditional Chinese herb.
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