Metabolic differences of industrial acarbose-producing Actinoplanes sp. A56 under various osmolality levels.

Kun-tai Li, Wei-fu Peng, Wei Xia, Lin Huang, Xin Cheng

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Article in World journal of microbiology & biotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Kun-tai LiNanchang Key Laboratory of Applied Fermentation Technology, Jiangxi Agricultural University, Nanchang, 330045, China.

Wei-fu PengNanchang Key Laboratory of Applied Fermentation Technology, Jiangxi Agricultural University, Nanchang, 330045, China.

Wei XiaNanchang Key Laboratory of Applied Fermentation Technology, Jiangxi Agricultural University, Nanchang, 330045, China.

Lin HuangNanchang Key Laboratory of Applied Fermentation Technology, Jiangxi Agricultural University, Nanchang, 330045, China.

Xin ChengNanchang Key Laboratory of Applied Fermentation Technology, Jiangxi Agricultural University, Nanchang, 330045, China. xinch27@sina.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many investigations have revealed that a certain concentration of osmolality was indispensable for efficient acarbose production, but little information was available on the response mechanism of acarbose-producing strains to osmotic stress. By using the gas chromatography-mass spectrometry (GC-MS) analysis coupled with the enzyme activity determination of central carbon metabolism, the present work investigated the metabolic characteristics of industrial acarbose-producing Actinoplanes sp. A56 under various osmolality levels. Relatively high osmolality (450-500 mOsm/kg) appeared to favor efficient acarbose production by Actinoplanes sp. A56, although it inhibited cell growth. Further GC-MS analysis showed that fatty acids were the uppermost differential intracellular metabolites under various osmolality levels, and the relatively high osmolality resulted in increases in levels of fatty acids.

Indexed as

Osmolar ConcentrationAcarboseBioreactorsCarbonFatty AcidsFermentationGas Chromatography-Mass SpectrometryGlycolysisHydrogen-Ion ConcentrationIndustrial MicrobiologyMaltoseMicromonosporaceaeMultigene FamilyOsmotic PressureOxygenAcarboseCarbonFatty AcidsMaltoseOxygenAcarboseActinoplanes sp. A56Metabolic responseOsmolality level

Identifiers

PMID26712618

DOI10.1007/s11274-015-1976-1

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