Trial reportAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology2016
Predictors of asthma exacerbation among patients with poorly controlled asthma despite inhaled corticosteroid treatment.
Trial report in Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Single inhaler with beclometasone, formoterol, and glycopyrronium versus triple therapies in adults with uncontrolled asthma: a systematic review and meta-analysis.Scientific reports · 2025Pooled it
- Pooled it
- The Role of Spirometry and MMEF in Pediatric Asthma Monitoring and Prediction of Exacerbations.Children (Basel, Switzerland) · 2025Article
- Impact of Effect Modification of Type 2 Inflammation and Sex on Asthma Exacerbation Rates.CHEST pulmonary · 2025Article
- Exploring the association between asthma and chronic comorbidities: impact on clinical outcomes.Frontiers in medicine · 2024Review
- Understanding the Clinical Implications of Individual Patient Characteristics and Treatment Choice on the Risk of Exacerbation in Asthma Patients with Moderate-Severe Symptoms.Advances in therapy · 2023Article
- Past asthma exacerbation in children predicting future exacerbation: a systematic review.ERJ open research · 2022Article
- Association of comorbidities and medications with risk of asthma exacerbation in pediatric patients: a retrospective study using Japanese claims data.Scientific reports · 2022Article
- Current unmet needs and potential solutions to uncontrolled asthma.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Asthma attacks in children are always preceded by poor asthma control: myth or maxim?Breathe (Sheffield, England) · 2020Article
- Investigation of the Effect of Asthma on Mortality and Morbidity After Coronary Artery Bypass Surgery.Turkish thoracic journal · 2020Article
- Association of elevated fractional exhaled nitric oxide concentration and blood eosinophil count with severe asthma exacerbations.Clinical and translational allergy · 2019Article
- Assessing health outcomes, quality of life, and healthcare use among school-age children with asthma.The Journal of asthma : official journal of the Association for the Care of Asthma · 2019Article
- Machine learning approaches to personalize early prediction of asthma exacerbations.Annals of the New York Academy of Sciences · 2017Article
- Factors Predicting Recovery From Asthma Exacerbations.Allergy, asthma & immunology research · 2016Article
- Comparison of fractional exhaled nitric oxide, spirometry, and Asthma Control Test, in predicting asthma exacerbations: A prospective cohort study.Lung India : official organ of Indian Chest SocietyArticle
- Asthma Exacerbations: Pathogenesis, Prevention, and Treatment.The journal of allergy and clinical immunology. In practiceReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundAsthma exacerbations are associated with decreased quality of life and increased health care usage. Identification of characteristics that predict increased risk of future exacerbations in patients with suboptimal control of asthma could guide treatment decisions.
objectiveTo examine patient characteristics associated with risk of asthma exacerbations in patients with uncontrolled persistent asthma.
methodsA retrospective analysis of adults and children with inadequately controlled asthma despite asthma controller therapy and enrolled in 2 randomized trials was conducted. Baseline characteristics of subjects who experienced an asthma exacerbation during the treatment period were compared with those of subjects who did not experience an exacerbation.
resultsOf 718 subjects (402 adults and 295 children), 108 adults (27%) and 110 children (37%) experienced an asthma exacerbation during the study period. Unscheduled health care visits for asthma or use of oral corticosteroids in the previous year were significantly associated with asthma exacerbation during the study period (P < .01). Adult subjects who experienced an exacerbation had significantly lower forced expiratory volume in 1 second compared with those who did not (2.3 vs 2.5 L, respectively, P = .02). Children who experienced an exacerbation had lower baseline pre- and post-bronchodilator ratios of forced expiratory volume in 1 second to forced vital capacity (77% vs 81%, P < .01; 82% vs 86%, P < .001, respectively). Symptom scores on validated questionnaires were significantly worse in adults but not in children who developed an exacerbation.
conclusionSpirometric measurements can help identify adults and children at increased risk for asthma exacerbation. Symptom scores could be helpful in identifying adults who are at high risk for exacerbations but could be less helpful in children.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.