ArticleChinese medical journal2016
A Trichophyton Rubrum Infection Model Based on the Reconstructed Human Epidermis - Episkin®.
Article in Chinese medical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 22 citations in OpenAlex.
- Biofilm development in three-dimensional models infected withMicrobiology spectrum · 2025Article
- In vitro characterization of Trichophyton rubrum biofilm by combined anti-biofilm enzymes.PloS one · 2025Article
- Innate immune responses against the fungal pathogen Candida auris.Nature communications · 2022Article
- Towards a Standardized Procedure for the Production of Infective Spores to Study the Pathogenesis of Dermatophytosis.Journal of fungi (Basel, Switzerland) · 2021Article
- Challenges in exploring and manipulating the human skin microbiome.Microbiome · 2021Review
- Human skin models: From healthy to disease-mimetic systems; characteristics and applications.British journal of pharmacology · 2020Review
- Corrigendum: A Trichophyton Rubrum infection model based on the reconstructed human epidermis - Episkin®.Chinese medical journal · 2019Article
- AnFrontiers in microbiology · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTrichophyton rubrum represents the most common infectious fungus responsible for dermatophytosis in human, but the mechanism involved is still not completely understood. An appropriate model constructed to simulate host infection is the prerequisite to study the pathogenesis of dermatophytosis caused by T. rubrum. In this study, we intended to develop a new T. rubrum infection model in vitro, using the three-dimensional reconstructed epidermis - EpiSkin ®, and to pave the way for further investigation of the mechanisms involved in T. rubrum infection.
methodsThe reconstructed human epidermis (RHE) was infected by inoculating low-dose (400 conidia) and high-dose (4000 conidia) T. rubrum conidia to optimize the infection dose. During the various periods after infection, the samples were processed for pathological examination and scanning electron microscopy (SEM) observation.
resultsThe histological analysis of RHE revealed a fully differentiated epidermis with a functional stratum corneum, which was analogous to the normal human epidermis. The results of hematoxylin and eosin staining and the periodic acid-Schiff staining showed that the infection dose of 400 conidia was in accord with the pathological characteristics of host dermatophytosis caused by T. rubrum. SEM observations further exhibited the process of T. rubrum infection in an intuitionistic way.
conclusionsWe established the T. rubrum infection model on RHE in vitro successfully. It is a promising model for further investigation of the mechanisms involved in T. rubrum infection.
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