ArticleInfection and immunity2015
Gene Models, Expression Repertoire, and Immune Response of Plasmodium vivax Reticulocyte Binding Proteins.
Article in Infection and immunity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Nanobodies against Plasmodium adhesins that block receptor engagement and malaria parasite invasion.The Biochemical journal · 2026Article
- Multiplex bead assays enable integrated serological surveillance and reveal cross-pathogen vulnerabilities in Zambezia Province, Mozambique.Nature communications · 2025Article
- Comparative transcriptomics reveal differential gene expression among Plasmodium vivax geographical isolates and implications on erythrocyte invasion mechanisms.PLoS neglected tropical diseases · 2024Article
- A new Plasmodium vivax reference genome for South American isolates.BMC genomics · 2023Article
- Genetic diversity of Plasmodium vivax reticulocyte binding protein 2b in global parasite populations.Parasites & vectors · 2022Article
- Naturally acquired antibody kinetics against Plasmodium vivax antigens in people from a low malaria transmission region in western Thailand.BMC medicine · 2022Article
- Review
- Article
- Naturally acquired blocking human monoclonal antibodies to Plasmodium vivax reticulocyte binding protein 2b.Nature communications · 2021Article
- Progress towards the development of aExpert review of vaccines · 2021Review
- Alternative Invasion Mechanisms and Host Immune Response toMicroorganisms · 2020Review
- Development and validation of serological markers for detecting recent Plasmodium vivax infection.Nature medicine · 2020Observational
- The Blood Stage Antigen RBP2-P1 of Plasmodium vivax Binds Reticulocytes and Is a Target of Naturally Acquired Immunity.Infection and immunity · 2020Article
- Plasmodium vivax transcriptional profiling of low input cryopreserved isolates through the intraerythrocytic development cycle.PLoS neglected tropical diseases · 2020Article
- Plasmodium vivax Reticulocyte Binding Proteins for invasion into reticulocytes.Cellular microbiology · 2020Review
- Antibodies to Plasmodium vivax reticulocyte binding protein 2b are associated with protection against P. vivax malaria in populations living in low malaria transmission regions of Brazil and Thailand.PLoS neglected tropical diseases · 2019Article
- Complement Receptor 1 availability on red blood cell surface modulates Plasmodium vivax invasion of human reticulocytes.Scientific reports · 2019Article
- Molecular and cellular interactions defining the tropism of Plasmodium vivax for reticulocytes.Current opinion in microbiology · 2018Review
- Evolutionary history of humanProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Transferrin receptor 1 is a reticulocyte-specific receptor forScience (New York, N.Y.) · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Members of the Plasmodium vivax reticulocyte binding protein (PvRBP) family are believed to mediate specific invasion of reticulocytes by P. vivax. In this study, we performed molecular characterization of genes encoding members of this protein family. Through cDNA sequencing, we constructed full-length gene models and verified genes that are protein coding and those that are pseudogenes. We also used quantitative PCR to measure their in vivo transcript abundances in clinical P. vivax isolates. Like genes encoding related invasion ligands of P. falciparum, Pvrbp expression levels vary broadly across different parasite isolates. Through antibody measurements, we found that host immune pressure may be the driving force behind the distinctly high diversity of one of the family members, PvRBP2c. Mild yet significant negative correlation was found between parasitemia and the PvRBP2b antibody level, suggesting that antibodies to the protein may interfere with invasion.
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