ArticleClinical lung cancer2016
Association Between Computed Tomographic Features and Kirsten Rat Sarcoma Viral Oncogene Mutations in Patients With Stage I Lung Adenocarcinoma and Their Prognostic Value.
Article in Clinical lung cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Review
- Depicting growth characteristics with computed tomography for KRAS-mutated lung adenocarcinoma.Quantitative imaging in medicine and surgery · 2025Article
- Review
- Multicellular ecotypes shape progression of lung adenocarcinoma from ground-glass opacity toward advanced stages.Cell reports. Medicine · 2024Article
- A narrative review on current imaging applications of artificial intelligence and radiomics in oncology: focus on the three most common cancers.La Radiologia medica · 2022Review
- Deep Radiotranscriptomics of Non-Small Cell Lung Carcinoma for Assessing Molecular and Histology Subtypes with a Data-Driven Analysis.Diagnostics (Basel, Switzerland) · 2021Article
- Prognostic value of ground glass opacity on computed tomography in pathological stage I pulmonary adenocarcinoma: A meta-analysis.World journal of clinical cases · 2021Article
- Analysis of the clinicopathological characteristics, genetic phenotypes, and prognostic of pure mucinous adenocarcinoma.Cancer medicine · 2020Article
- Dual-energy spectral CT characteristics in surgically resected lung adenocarcinoma: comparison between Kirsten rat sarcoma viral oncogene mutations and epidermal growth factor receptor mutations.Cancer imaging : the official publication of the International Cancer Imaging Society · 2019Article
- Delta radiomic features improve prediction for lung cancer incidence: A nested case-control analysis of the National Lung Screening Trial.Cancer medicine · 2018Article
- Prognostic value and molecular correlates of a CT image-based quantitative pleural contact index in early stage NSCLC.European radiology · 2018Article
- Computer-Aided Nodule Assessment and Risk Yield (CANARY) may facilitate non-invasive prediction of EGFR mutation status in lung adenocarcinomas.Scientific reports · 2017Article
- Radial gradient and radial deviation radiomic features from pre-surgical CT scans are associated with survival among lung adenocarcinoma patients.Oncotarget · 2017Article
- Somatic Mutations Drive Distinct Imaging Phenotypes in Lung Cancer.Cancer research · 2017Article
- Associations between radiologist-defined semantic and automatically computed radiomic features in non-small cell lung cancer.Scientific reports · 2017Article
- Pulmonary ground-glass opacity: computed tomography features, histopathology and molecular pathology.Translational lung cancer research · 2017Review
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundWe investigated the association between computed tomographic (CT) features and Kirsten rat sarcoma viral oncogene (KRAS) mutations in patients with stage I lung adenocarcinoma and their prognostic value. PATIENTS AND
methodsA total of 79 patients with pathologic stage I lung adenocarcinoma, available KRAS mutational status, preoperative CT images available, and survival data were included in the present study. Seven CT features, including spiculation, concavity, ground-glass opacity, bubble-like lucency, air bronchogram, pleural retraction, and pleural attachment, were evaluated. The association among the clinical characteristics, CT features, and mutational status was analyzed using Student's t test, the χ(2) test or Fisher's exact test, and logistic regression. The association among CT features, mutational status, and overall survival was analyzed using Kaplan-Meier survival curves with the log-rank test and Cox proportional hazard regression.
resultsThe prevalence of KRAS mutations was 41.77%. Spiculation was significantly associated with the presence of KRAS mutations (odds ratio, 2.99; 95% confidence interval [CI], 1.16-7.68). Although KRAS mutational status was not significantly associated with overall survival, the presence of pleural attachment was associated with an increased risk of death (hazard ratio, 2.46; 95% CI, 1.09-5.53). When analyzing KRAS mutational status and pleural attachment combined, patients with wild-type KRAS and no pleural attachment had significantly better survival than did those with wild-type KRAS and pleural attachment (P = .014).
conclusionThese data suggest that spiculation is associated with KRAS mutations and pleural attachment is associated with overall survival in patients with stage I lung adenocarcinoma. Combining the analysis of KRAS mutational status and CT features could better predict survival.
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