ArticleProceedings of the National Academy of Sciences of the United States of America2016
Genetic contributions to circadian activity rhythm and sleep pattern phenotypes in pedigrees segregating for severe bipolar disorder.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Time perception in bipolar disorder: a systematic review.Acta neuropsychiatrica · 2025Pooled it
- Human CRY1 variants associate with attention deficit/hyperactivity disorder.The Journal of clinical investigation · 2020Trial
- Polygenic risk scores for mood disorders and actigraphy estimates of sleep and circadian rhythms: A preliminary study in bipolar disorders.Journal of sleep research · 2025Article
- The interaction network and potential clinical effectiveness of dimensional psychopathology phenotyping based on EMR: a Bayesian network approach.BMC psychiatry · 2025Article
- Differential serum levels of CACNA1C, circadian rhythm and stress response molecules in subjects with bipolar disorder: Associations with genetic and clinical factors.Journal of affective disorders · 2024Article
- Differential Serum Levels of CACNA1C, Circadian Rhythm and Stress Response Molecules in Subjects with Bipolar Disorder: Associations with Genetic and Clinical Factors.medRxiv : the preprint server for health sciences · 2024Article
- The sleep-circadian interface: A window into mental disorders.Proceedings of the National Academy of Sciences of the United States of America · 2024Review
- Neuropsychiatric disorders, chronotype and sleep: A narrative review of GWAS findings and the application of Mendelian randomization to investigate causal relationships.Genes, brain, and behavior · 2024Review
- Neurobehavioral Reward and Sleep-Circadian Profiles Predict Present and Next-Year Mania/Hypomania Symptoms.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Does circadian dysrhythmia drive the switch into high- or low-activation states in bipolar I disorder?Bipolar disorders · 2023Review
- Regulation of dendritic spines in the amygdala following sleep deprivation.Frontiers in sleep · 2023Article
- TWO-SAMPLE TESTS FOR MULTIVARIATE REPEATED MEASUREMENTS OF HISTOGRAM OBJECTS WITH APPLICATIONS TO WEARABLE DEVICE DATA.The annals of applied statistics · 2022Article
- Depression and bipolar disorder subtypes differ in their genetic correlations with biological rhythms.Scientific reports · 2022Article
- The impact of lithium on circadian rhythms and implications for bipolar disorder pharmacotherapy.Neuroscience letters · 2022Review
- Phenotypes, mechanisms and therapeutics: insights from bipolar disorder GWAS findings.Molecular psychiatry · 2022Review
- Neurobiological and behavioral mechanisms of circadian rhythm disruption in bipolar disorder: A critical multi-disciplinary literature review and agenda for future research from the ISBD task force on chronobiology.Bipolar disorders · 2022Review
- Which Actigraphy Dimensions Predict Longitudinal Outcomes in Bipolar Disorders?Journal of clinical medicine · 2022Article
- Blue Light Blocking Treatment for the Treatment of Bipolar Disorder: Directions for Research and Practice.Journal of clinical medicine · 2022Review
- Association between circadian activity rhythms and mood episode relapse in bipolar disorder: a 12-month prospective cohort study.Translational psychiatry · 2021Article
- Genome-wide mapping of brain phenotypes in extended pedigrees with strong genetic loading for bipolar disorder.Molecular psychiatry · 2021Article
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Authors and funding
34 authors.
Lucia PaganiDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390;
Patricia A St ClairDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095;
Terri M TeshibaDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095;
Susan K ServiceDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095;
Scott C FearsDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095;
Carmen ArayaCell and Molecular Biology Research Center, Universidad de Costa Rica, San Pedro de Montes de Oca, San José, Costa Rica 11501;
Xinia ArayaCell and Molecular Biology Research Center, Universidad de Costa Rica, San Pedro de Montes de Oca, San José, Costa Rica 11501;
Julio BejaranoCell and Molecular Biology Research Center, Universidad de Costa Rica, San Pedro de Montes de Oca, San José, Costa Rica 11501;
Margarita RamirezCell and Molecular Biology Research Center, Universidad de Costa Rica, San Pedro de Montes de Oca, San José, Costa Rica 11501;
Gabriel CastrillónInstituto de Alta Tecnología Médica de Antioquia, Medellín, Colombia 050026;
Juliana Gomez-MakhinsonGrupo de Investigación en Psiquiatría (Research Group in Psychiatry; GIPSI), Departamento de Psiquiatría Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia 050011;
Maria C LopezGrupo de Investigación en Psiquiatría (Research Group in Psychiatry; GIPSI), Departamento de Psiquiatría Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia 050011;
Gabriel MontoyaGrupo de Investigación en Psiquiatría (Research Group in Psychiatry; GIPSI), Departamento de Psiquiatría Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia 050011;
Claudia P MontoyaGrupo de Investigación en Psiquiatría (Research Group in Psychiatry; GIPSI), Departamento de Psiquiatría Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia 050011;
Ileana AldanaDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095;
Linda NavarroDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095;
Daniel G FreimerDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095;
Brian SafaieDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095;
Lap-Woon KeungDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095;
Kiefer GreenspanDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095;
Katty ChouDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095;
Javier I EscobarDepartment of Psychiatry and Family Medicine, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ 08901;
Jorge Ospina-DuqueGrupo de Investigación en Psiquiatría (Research Group in Psychiatry; GIPSI), Departamento de Psiquiatría Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia 050011;
Barbara KremeyerDepartment of Genetics, Evolution and Environment, University College London, London WC1E 6BT, United Kingdom;
Andres Ruiz-LinaresDepartment of Genetics, Evolution and Environment, University College London, London WC1E 6BT, United Kingdom;
Rita M CantorDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095;
Carlos Lopez-JaramilloGrupo de Investigación en Psiquiatría (Research Group in Psychiatry; GIPSI), Departamento de Psiquiatría Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia 050011; Mood Disorders Program, Hospital San Vicente Fundacion, Medellín, Colombia 050011;
Gabriel MacayaCell and Molecular Biology Research Center, Universidad de Costa Rica, San Pedro de Montes de Oca, San José, Costa Rica 11501;
Julio MolinaBioCiencias Lab, 01010 Guatemala, Guatemala;
Victor I ReusDepartment of Psychiatry, University of California, San Francisco, CA 94143;
Chiara SabattiDepartment of Health Research and Policy, Division of Biostatistics, Stanford University, Stanford, CA 94305;
Carrie E BeardenDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095;
Joseph S TakahashiDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390 joseph.takahashi@utsouthwestern.edu nfreimer@mednet.ucla.edu.
Nelson B FreimerDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095; joseph.takahashi@utsouthwestern.edu nfreimer@mednet.ucla.edu.
Funding
Integrative Center for Neurogenetics and Neurogenomics - OverallP30NS062691 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ESKIN, ELEAZAR · 2009 to 2018
$7.4MGenetics of Severe Mental IllnessR01MH113078 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E, FREIMER, NELSON B. · 2017 to 2021
$5.8MBipolar Endophenotypes in Population IsolatesR01MH075007 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FREIMER, NELSON B. · 2007 to 2011
$3.8MGenome Sequencing in Extended Bipolar PedigreesR01MH095454 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FREIMER, NELSON B. · 2012 to 2014
$2.4MTraining Grant in Neurobehavioral GeneticsT32MH073526 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E, GESCHWIND, DANIEL H · 2006 to 2020
$2.4MNew Statistical Methods for High Resolution Mapping of Multiple PhenotypesR01HG006695 · NHGRI · STANFORD UNIVERSITY · PI SABATTI, CHIARA · 2013 to 2015
$1.0MQuantitative Genetic Analyisis of Brain Structural PhenotypesK08MH086786 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FEARS, SCOTT C. · 2009 to 2013
$925kIdentification of endophenotypes for bipolar disorderK23MH074644 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E · 2005 to 2009
$808kHoward Hughes Medical InstituteNHGRI NIH HHS R01 HG006695NIMH NIH HHS K08MH08NIMH NIH HHS K08 MH086786NIMH NIH HHS K23 MH074644NIMH NIH HHS K23MH074644-01NIMH NIH HHS R01 MH075007NIMH NIH HHS R01MH075007NIMH NIH HHS R01 MH095454NIMH NIH HHS R01MH095454NIMH NIH HHS R01 MH113078NIMH NIH HHS T32 MH073526NIMH NIH HHS T32MH073526NINDS NIH HHS P30 NS062691NINDS NIH HHS P30NS062691
Abstract
Abnormalities in sleep and circadian rhythms are central features of bipolar disorder (BP), often persisting between episodes. We report here, to our knowledge, the first systematic analysis of circadian rhythm activity in pedigrees segregating severe BP (BP-I). By analyzing actigraphy data obtained from members of 26 Costa Rican and Colombian pedigrees [136 euthymic (i.e., interepisode) BP-I individuals and 422 non-BP-I relatives], we delineated 73 phenotypes, of which 49 demonstrated significant heritability and 13 showed significant trait-like association with BP-I. All BP-I-associated traits related to activity level, with BP-I individuals consistently demonstrating lower activity levels than their non-BP-I relatives. We analyzed all 49 heritable phenotypes using genetic linkage analysis, with special emphasis on phenotypes judged to have the strongest impact on the biology underlying BP. We identified a locus for interdaily stability of activity, at a threshold exceeding genome-wide significance, on chromosome 12pter, a region that also showed pleiotropic linkage to two additional activity phenotypes.
Indexed as
Circadian RhythmSleepActigraphyBipolar DisorderChromosomes, Human, Pair 1FamilyFemaleHumansInheritance PatternsLod ScoreMaleMiddle AgedPedigreePhenotypeQuantitative Trait, Heritableactigraphybehaviorbipolar disordercircadian rhythmsendophenotypes
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