ArticleProceedings of the National Academy of Sciences of the United States of America2016
Gsα deficiency in adipose tissue improves glucose metabolism and insulin sensitivity without an effect on body weight.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Cox10-mediated mitochondrial respiration in brown adipocytes regulates adaptive thermogenesis and systemic metabolism.iScience · 2026Article
- Macrophage Gsα promotes NLRP3 stability and its intervention attenuates abdominal aortic aneurysm in male mice.Nature communications · 2026Article
- Inside the Biology of the β3-Adrenoceptor.Biomolecules · 2024Review
- Article
- Adipocyte G Protein-Coupled Receptors as Potential Targets for Novel Antidiabetic Drugs.Diabetes · 2023Review
- A novel phenolic formulation for treating hepatic and peripheral insulin resistance by regulating GLUT4-mediated glucose uptake.Journal of traditional and complementary medicine · 2022Article
- Clenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells.Nature communications · 2022Article
- Endothelial G protein stimulatory α-subunit is a critical regulator of post-ischemic angiogenesis.Frontiers in cardiovascular medicine · 2022Article
- Chemogenetic approaches to identify metabolically important GPCR signaling pathways: Therapeutic implications.Journal of neurochemistry · 2021Review
- A thermogenic fat-epithelium cell axis regulates intestinal disease tolerance.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- STAT5 is required for lipid breakdown and beta-adrenergic responsiveness of brown adipose tissue.Molecular metabolism · 2020Article
- Single-Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis.Cell reports · 2020Article
- Control of Adipocyte Thermogenesis and Lipogenesis through β3-Adrenergic and Thyroid Hormone Signal Integration.Cell reports · 2020Article
- Adipocyte Gs but not Gi signaling regulates whole-body glucose homeostasis.Molecular metabolism · 2019Article
- Skeletal Muscle-Specific Activation of GDiabetes · 2019Article
- Sympathetic inputs regulate adaptive thermogenesis in brown adipose tissue through cAMP-Salt inducible kinase axis.Scientific reports · 2018Article
- The stimulatory G protein GThe Journal of biological chemistry · 2018Article
- Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism.Nature cell biology · 2018Article
- Glucocorticoid Receptor and Adipocyte Biology.Nuclear receptor research · 2018Article
- Adipocyte STAT5 deficiency promotes adiposity and impairs lipid mobilisation in mice.Diabetologia · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Gsα, the G protein that transduces receptor-stimulated cAMP generation, mediates sympathetic nervous system stimulation of brown adipose tissue (BAT) thermogenesis and browning of white adipose tissue (WAT), which are both potential targets for treating obesity, as well as lipolysis. We generated a mouse line with Gsα deficiency in mature BAT and WAT adipocytes (Ad-GsKO). Ad-GsKO mice had impaired BAT function, absent browning of WAT, and reduced lipolysis, and were therefore cold-intolerant. Despite the presence of these abnormalities, Ad-GsKO mice maintained normal energy balance on both standard and high-fat diets, associated with decreases in both lipolysis and lipid synthesis. In addition, Ad-GsKO mice maintained at thermoneutrality on a standard diet also had normal energy balance. Ad-GsKO mice had improved insulin sensitivity and glucose metabolism, possibly secondary to the effects of reduced lipolysis and lower circulating fatty acid binding protein 4 levels. Gsα signaling in adipose tissues may therefore affect whole-body glucose metabolism in the absence of an effect on body weight.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.