Evidence map›Paper›PMID 26711897›Full record

ArticleEnvironmental microbiology reports2016

Intraclonal genome diversity of the major Pseudomonas aeruginosa clones C and PA14.

Sebastian Fischer, Jens Klockgether, Patricia Morán Losada, Philippe Chouvarine, Nina Cramer, Colin F Davenport, Sarah Dethlefsen, Marie Dorda, Alexander Goesmann, Rolf Hilker and 7 more

Open access · hybridAbstract read
In one paragraph

Article in Environmental microbiology reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 42 citations in OpenAlex.

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  3. AvirulentmicroLife · 2025
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  6. Structural genome variants ofFrontiers in microbiology · 2023
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  8. Synergy BetweenFrontiers in cellular and infection microbiology · 2022
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  9. Article
  10. Pathogens (Basel, Switzerland) · 2021
    Article
  11. Review
  12. Article
  13. Article
  14. Sequence diversity of theAccess microbiology · 2021
    Article
  15. Article
  16. Review
  17. A comparative genomics approach identifies contact-dependent growth inhibition as a virulence determinant.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Sebastian FischerClinical Research Group 'Molecular Pathology of Cystic Fibrosis and Pseudomonas Genomics', OE 6710, Hannover Medical School, Hannover, Germany.
Jens KlockgetherClinical Research Group 'Molecular Pathology of Cystic Fibrosis and Pseudomonas Genomics', OE 6710, Hannover Medical School, Hannover, Germany.
Patricia Morán LosadaClinical Research Group 'Molecular Pathology of Cystic Fibrosis and Pseudomonas Genomics', OE 6710, Hannover Medical School, Hannover, Germany.
Philippe ChouvarineClinical Research Group 'Molecular Pathology of Cystic Fibrosis and Pseudomonas Genomics', OE 6710, Hannover Medical School, Hannover, Germany.
Nina CramerClinical Research Group 'Molecular Pathology of Cystic Fibrosis and Pseudomonas Genomics', OE 6710, Hannover Medical School, Hannover, Germany.
Colin F DavenportClinical Research Group 'Molecular Pathology of Cystic Fibrosis and Pseudomonas Genomics', OE 6710, Hannover Medical School, Hannover, Germany.
Sarah DethlefsenClinical Research Group 'Molecular Pathology of Cystic Fibrosis and Pseudomonas Genomics', OE 6710, Hannover Medical School, Hannover, Germany.
Marie DordaClinical Research Group 'Molecular Pathology of Cystic Fibrosis and Pseudomonas Genomics', OE 6710, Hannover Medical School, Hannover, Germany.
Alexander GoesmannBioinformatics and Systems Biology, Justus-Liebig-Universität, Gießen, Germany.
Rolf HilkerBioinformatics and Systems Biology, Justus-Liebig-Universität, Gießen, Germany.
Samira MielkeClinical Research Group 'Molecular Pathology of Cystic Fibrosis and Pseudomonas Genomics', OE 6710, Hannover Medical School, Hannover, Germany.
Torben SchönfelderClinical Research Group 'Molecular Pathology of Cystic Fibrosis and Pseudomonas Genomics', OE 6710, Hannover Medical School, Hannover, Germany.
Sebastian SuerbaumInstitute for Medical Microbiology and Hospital Epidemiology, OE 5210, Hannover Medical School, Hannover, Germany.
Oliver TürkClinical Research Group 'Molecular Pathology of Cystic Fibrosis and Pseudomonas Genomics', OE 6710, Hannover Medical School, Hannover, Germany.
Sabrina WoltemateInstitute for Medical Microbiology and Hospital Epidemiology, OE 5210, Hannover Medical School, Hannover, Germany.
Lutz WiehlmannClinical Research Group 'Molecular Pathology of Cystic Fibrosis and Pseudomonas Genomics', OE 6710, Hannover Medical School, Hannover, Germany.
Burkhard TümmlerClinical Research Group 'Molecular Pathology of Cystic Fibrosis and Pseudomonas Genomics', OE 6710, Hannover Medical School, Hannover, Germany.
Medizinische Hochschule Hannover · DEJustus-Liebig-Universität Gießen · DEGerman Center for Lung Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial populations differentiate at the subspecies level into clonal complexes. Intraclonal genome diversity was studied in 100 isolates of the two dominant Pseudomonas aeruginosa clones C and PA14 collected from the inanimate environment, acute and chronic infections. The core genome was highly conserved among clone members with a median pairwise within-clone single nucleotide sequence diversity of 8 × 10(-6) for clone C and 2 × 10(-5) for clone PA14. The composition of the accessory genome was, on the other hand, as variable within the clone as between unrelated clones. Each strain carried a large cargo of unique genes. The two dominant worldwide distributed P. aeruginosa clones combine an almost invariant core with the flexible gain and loss of genetic elements that spread by horizontal transfer.

Indexed as

Genetic VariationGenotypeConserved SequenceEnvironmental MicrobiologyGene Transfer, HorizontalGenome, BacterialHumansPseudomonas aeruginosaPseudomonas Infections

Identifiers

PMID26711897
PMCPMC4819714
OpenAlexW2304387506

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.