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ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2016

The EORTC QLQ-CR29 quality of life questionnaire for colorectal cancer: validation of the Dutch version.

A M Stiggelbout, M Kunneman, M C M Baas-Thijssen, P A Neijenhuis, A K Loor, S Jägers, R Vree, C A M Marijnen, A H Pieterse

Abstract readValidation Study
In one paragraph

Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Measuring health-related quality of life in colorectal cancer patients: systematic review of measurement properties of the EORTC QLQ-CR29.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
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  7. Quality of life assessment for colorectal cancer follow-up: A latent profile analysis of EORTC measures.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026
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  8. Quality of life following total neoadjuvant therapy for rectal cancer.Journal of cancer research and clinical oncology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

A M StiggelboutDepartment of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands. a.m.stiggelbout@lumc.nl.
M KunnemanDepartment of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands.
M C M Baas-ThijssenDepartment of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands.
P A NeijenhuisDepartment of Surgery, Alrijne Hospital Leiderdorp (Location Rijnland), Leiderdorp, The Netherlands.
A K LoorDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
S JägersClinical Trial Center, Erasmus Medical Center Cancer Center, Rotterdam, The Netherlands.
R VreeDepartment of Surgery, Alrijne Hospital Leiden (Location Diaconessen), Leiden, The Netherlands.
C A M MarijnenDepartment of Radiotherapy, Leiden University Medical Center, Leiden, The Netherlands.
A H PieterseDepartment of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo validate the Dutch version of the EORTC QLQ-CR29 quality of life questionnaire for colorectal cancer.

methodsWe translated and pilot-tested the original questionnaire in the Netherlands, following EORTC guidelines. We assessed factor structure, reliability and construct validity in different samples of patients from four hospitals.

resultsOf 296 patients, 236 (80 %) returned the questionnaire, and 27 out of 48 patients returned the retest questionnaire. In addition to the original three scales, we found a reliable bowel functioning scale (α = 0.80), reducing the number of individual items by five. Two of the other scales had sufficient to good reliability (urinary frequency, α = 0.71, original α = 0.75, body image α = 0.80, original α = 0.84), the third, blood and mucus in stool, only moderate (α = 0.56, original α = 0.69). Item functioning was sufficient to excellent for all but two items (urinary incontinence and dysuria). Construct validity was similar to that in earlier studies.

conclusionWe found a very satisfactory scale for bowel problems, in patients both with and without stoma. The body image and urinary incontinence scales were reliable, and construct validity was sufficient. We suggest the questionnaire to be adapted to decrease the number of individual items, improve the scales, and therefore increase reliability of the entire questionnaire.

Indexed as

Surveys and QuestionnairesAdultAgedBody ImageColorectal NeoplasmsEthnicityFemaleHumansMaleMiddle AgedNetherlandsPsychometricsQuality of LifeReproducibility of ResultsTranslationsUrinary IncontinenceColorectal cancerHealth-related quality of lifeQLQ-CR29Validation

Identifiers

PMID26711791
PMCPMC4893365

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.