ArticleAntimicrobial agents and chemotherapy2015
Activation of Melanin Synthesis in Alternaria infectoria by Antifungal Drugs.
Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 52 citations in OpenAlex.
- Review
- An Overview of theJournal of fungi (Basel, Switzerland) · 2026Review
- Solid-State NMR Reveals Reorganization of the Aspergillus fumigatus Cell Wall Due to a Host-Defence Peptide.Angewandte Chemie (International ed. in English) · 2025Article
- Caffeine Protects Keratinocytes fromInternational journal of molecular sciences · 2024Article
- Production and characterization of melanin pigment from black fungus Curvularia soli AS21 ON076460 assisted gamma rays for promising medical uses.Microbial cell factories · 2024Article
- Repurposing Benzimidazoles against Causative Agents of Chromoblastomycosis: Albendazole Has Superior In Vitro Activity Than Mebendazole and Thiabendazole.Journal of fungi (Basel, Switzerland) · 2023Article
- A Melanin-Deficient Isolate ofJournal of fungi (Basel, Switzerland) · 2022Article
- Effect of Melanin Biosynthesis Inhibition on the Antifungal Susceptibility of Chromoblastomycosis Agents.Antimicrobial agents and chemotherapy · 2021Article
- Antifungal and Anti-Inflammatory Potential ofAntibiotics (Basel, Switzerland) · 2021Article
- Pyomelanin Synthesis inFrontiers in microbiology · 2021Article
- Madurella mycetomatis causing eumycetoma medical treatment: The challenges and prospects.PLoS neglected tropical diseases · 2020Review
- Cytotoxic activity of crude extracts from Datura stramonium's fungal endophytes against A549 lung carcinoma and UMG87 glioblastoma cell lines and LC-QTOF-MS/MS based metabolite profiling.BMC complementary and alternative medicine · 2019Article
- Cross-resistance of the pathogenic fungus Alternaria alternata to fungicides with different modes of action.BMC microbiology · 2019Article
- Early Interaction of Alternaria infectoria Conidia with Macrophages.Mycopathologia · 2019Article
- Development of an Expression Vector to Overexpress or Downregulate Genes inJournal of fungi (Basel, Switzerland) · 2018Article
- Spondyloarthritis, Acute Anterior Uveitis, and Fungi: Updating the Catterall-King Hypothesis.Frontiers in medicine · 2018Article
- The Cell Biology of theFrontiers in cellular and infection microbiology · 2017Review
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Authors and funding
9 authors at 4 institutions in 3 countries.
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Abstract
The importance of Alternaria species fungi to human health ranges from their role as etiological agents of serious infections with poor prognoses in immunosuppressed individuals to their association with respiratory allergic diseases. The present work focuses on Alternaria infectoria, which was used as a model organism of the genus, and was designed to unravel melanin production in response to antifungals. After we characterized the pigment produced by A. infectoria, we studied the dynamics of 1,8-dihydroxynaphthalene (DHN)-melanin production during growth, the degree of melanization in response to antifungals, and how melanization affected susceptibility to several classes of therapeutic drugs. We demonstrate that A. infectoria increased melanin deposition in cell walls in response to nikkomycin Z, caspofungin, and itraconazole but not in response to fluconazole or amphotericin B. These results indicate that A. infectoria activates DHN-melanin synthesis in response to certain antifungal drugs, possibly as a protective mechanism against these drugs. Inhibition of DHN-melanin synthesis by pyroquilon resulted in a lower minimum effective concentration (MEC) of caspofungin and enhanced morphological changes (increased hyphal balloon size), characterized by thinner and less organized A. infectoria cell walls. In summary, A. infectoria synthesizes melanin in response to certain antifungal drugs, and its susceptibility is influenced by melanization, suggesting the therapeutic potential of drug combinations that affect melanin synthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.