Evidence map›Paper›PMID 26711739›Full record

ArticleHypertension (Dallas, Tex. : 1979)2016

Role of the Gut Microbiome in Obstructive Sleep Apnea-Induced Hypertension.

David J Durgan, Bhanu P Ganesh, Julia L Cope, Nadim J Ajami, Sharon C Phillips, Joseph F Petrosino, Emily B Hollister, Robert M Bryan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 192 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
192citing papers in PubMed, 7 pooled it
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

192 citing papers in PubMed, 7 syntheses or guidelines pooled it, 329 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Trial
  9. Trial
  10. Review
  11. Article
  12. Obstructive sleep apnea and primary snoring in children are associated with oropharyngeal dysbiosis and a mild compositional imbalance in the gastrointestinal tract.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026
    Article
  13. Article
  14. Mechanisms underlying end-organ injury in sleep apnoea.The European respiratory journal · 2026
    Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review

132 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

David J DurganFrom the Departments of Anesthesiology (D.J.D., S.C.P., R.M.B.), Pathology and Immunology (B.P.G., J.L.C., E.B.H.), Molecular Physiology and Biophysics (R.M.B.), The Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology (N.J.A., J.F.P.), and Texas Children's Microbiome Center, Department of Pathology, Baylor College of Medicine, Houston (J.L.C., E.B.H.); and Department of Medicine, Texas Children's Hospital, Houston (J.L.C., E.B.H.). durgan@bcm.edu.
Bhanu P GaneshFrom the Departments of Anesthesiology (D.J.D., S.C.P., R.M.B.), Pathology and Immunology (B.P.G., J.L.C., E.B.H.), Molecular Physiology and Biophysics (R.M.B.), The Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology (N.J.A., J.F.P.), and Texas Children's Microbiome Center, Department of Pathology, Baylor College of Medicine, Houston (J.L.C., E.B.H.); and Department of Medicine, Texas Children's Hospital, Houston (J.L.C., E.B.H.).
Julia L CopeFrom the Departments of Anesthesiology (D.J.D., S.C.P., R.M.B.), Pathology and Immunology (B.P.G., J.L.C., E.B.H.), Molecular Physiology and Biophysics (R.M.B.), The Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology (N.J.A., J.F.P.), and Texas Children's Microbiome Center, Department of Pathology, Baylor College of Medicine, Houston (J.L.C., E.B.H.); and Department of Medicine, Texas Children's Hospital, Houston (J.L.C., E.B.H.).
Nadim J AjamiFrom the Departments of Anesthesiology (D.J.D., S.C.P., R.M.B.), Pathology and Immunology (B.P.G., J.L.C., E.B.H.), Molecular Physiology and Biophysics (R.M.B.), The Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology (N.J.A., J.F.P.), and Texas Children's Microbiome Center, Department of Pathology, Baylor College of Medicine, Houston (J.L.C., E.B.H.); and Department of Medicine, Texas Children's Hospital, Houston (J.L.C., E.B.H.).
Sharon C PhillipsFrom the Departments of Anesthesiology (D.J.D., S.C.P., R.M.B.), Pathology and Immunology (B.P.G., J.L.C., E.B.H.), Molecular Physiology and Biophysics (R.M.B.), The Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology (N.J.A., J.F.P.), and Texas Children's Microbiome Center, Department of Pathology, Baylor College of Medicine, Houston (J.L.C., E.B.H.); and Department of Medicine, Texas Children's Hospital, Houston (J.L.C., E.B.H.).
Joseph F PetrosinoFrom the Departments of Anesthesiology (D.J.D., S.C.P., R.M.B.), Pathology and Immunology (B.P.G., J.L.C., E.B.H.), Molecular Physiology and Biophysics (R.M.B.), The Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology (N.J.A., J.F.P.), and Texas Children's Microbiome Center, Department of Pathology, Baylor College of Medicine, Houston (J.L.C., E.B.H.); and Department of Medicine, Texas Children's Hospital, Houston (J.L.C., E.B.H.).
Emily B HollisterFrom the Departments of Anesthesiology (D.J.D., S.C.P., R.M.B.), Pathology and Immunology (B.P.G., J.L.C., E.B.H.), Molecular Physiology and Biophysics (R.M.B.), The Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology (N.J.A., J.F.P.), and Texas Children's Microbiome Center, Department of Pathology, Baylor College of Medicine, Houston (J.L.C., E.B.H.); and Department of Medicine, Texas Children's Hospital, Houston (J.L.C., E.B.H.).
Robert M BryanFrom the Departments of Anesthesiology (D.J.D., S.C.P., R.M.B.), Pathology and Immunology (B.P.G., J.L.C., E.B.H.), Molecular Physiology and Biophysics (R.M.B.), The Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology (N.J.A., J.F.P.), and Texas Children's Microbiome Center, Department of Pathology, Baylor College of Medicine, Houston (J.L.C., E.B.H.); and Department of Medicine, Texas Children's Hospital, Houston (J.L.C., E.B.H.).
Baylor College of Medicine · US

Funding

Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Geoffrey A Preidis · 2001 to 2026
$28.3M
Effects of obstructive sleep apnea on cerebral circulationR01NS080531 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI BRYAN, ROBERT M · 2012 to 2016
$1.7M
Cerebral small vessel disease, obstructive sleep apnea, and the gastrointestinal systemR21NS094806 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI BRYAN, ROBERT M · 2015 to 2016
$436k
NIDDK NIH HHS DK56338NIDDK NIH HHS P30 DK056338NINDS NIH HHS R01 NS080531NINDS NIH HHS R01NS080531NINDS NIH HHS R21 NS094806
6 · The paper itself

Abstract

Individuals suffering from obstructive sleep apnea (OSA) are at increased risk for systemic hypertension. The importance of a healthy gut microbiota, and detriment of a dysbiotic microbiota, on host physiology is becoming increasingly evident. We tested the hypothesis that gut dysbiosis contributes to hypertension observed with OSA. OSA was modeled in rats by inflating a tracheal balloon during the sleep cycle (10-s inflations, 60 per hour). On normal chow diet, OSA had no effect on blood pressure; however, in rats fed a high-fat diet, blood pressure increased 24 and 29 mm Hg after 7 and 14 days of OSA, respectively (P<0.05 each). Bacterial community characterization was performed on fecal pellets isolated before and after 14 days of OSA in chow and high-fat fed rats. High-fat diet and OSA led to significant alterations of the gut microbiota, including decreases in bacterial taxa known to produce the short chain fatty acid butyrate (P<0.05). Finally, transplant of dysbiotic cecal contents from hypertensive OSA rats on high-fat diet into OSA recipient rats on normal chow diet (shown to be normotensive) resulted in hypertension similar to that of the donor (increased 14 and 32 mm Hg after 7 and 14 days of OSA, respectively; P<0.05). These studies demonstrate a causal relationship between gut dysbiosis and hypertension, and suggest that manipulation of the microbiota may be a viable treatment for OSA-induced, and possibly other forms of, hypertension.

Indexed as

AnimalsBlood PressureDisease Models, AnimalDysbiosisGastrointestinal MicrobiomeHypertensionMalePolysomnographyRatsRats, Long-EvansSleepSleep Apnea Syndromesbutyratesdysbiosishypertensionmicrobiotaobstructive sleep apnea

Identifiers

PMID26711739
PMCPMC4713369
OpenAlexW2225428785

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.