Evidence map›Paper›PMID 26711696›Full record

ReviewCurrent rheumatology reports2016

Recent Developments in the Classification, Evaluation, Pathophysiology, and Management of Scleroderma Renal Crisis.

Cybele Ghossein, John Varga, Andrew Z Fenves

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current rheumatology reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Complement in Secondary Thrombotic Microangiopathy.Kidney international reports · 2021
    Review
  2. Article
  3. Review
  4. Article
  5. Thrombotic Microangiopathy and the Kidney.Clinical journal of the American Society of Nephrology : CJASN · 2018
    Review
  6. Kidney involvement in systemic sclerosis: From pathogenesis to treatment.Journal of scleroderma and related disorders · 2018
    Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Cybele GhosseinDepartment of Medicine, Division of Nephrology, Northwestern University, Feinberg School of Medicine, 710 North Fairbanks Court-Suite 4500, Chicago, IL, 60611, USA. c-ghossein@northwestern.edu.
John VargaDepartment of Medicine, Northwestern University, Feinberg School of Medicine, 240 E Huron Street McGaw Pavilion Rheumatology M300, Chicago, IL, 60611, USA. j-varga@northwestern.edu.
Andrew Z FenvesDepartment of Medicine, Massachusetts General Hospital, Harvard Medical School, 50 Staniford Street, Suite 503B, Boston, MA, 02114, USA. AFENVES@mgh.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Scleroderma renal crisis (SRC) is an uncommon complication of systemic sclerosis. Despite the advent of angiotensin-converting inhibitor therapy, SRC remains a life-threatening complication. Recent studies have contributed to a better understanding of SRC, but much remains unknown regarding its pathophysiology, risk factors, and optimal management. Genetic studies provide evidence that immune dysregulation might be a contributing factor, providing hope that further research in this direction might illuminate pathogenesis and provide novel predictors for this complication.

Indexed as

Acute Kidney InjuryAngiotensin-Converting Enzyme InhibitorsHumansKidney TransplantationPrognosisRisk FactorsScleroderma, SystemicAngiotensin-Converting Enzyme InhibitorsAngiotensin-converting enzyme inhibitor (ACEI)Diffuse cutaneous disease (dcSSc)Immune dysregulationMalignant hypertensionRenal biopsyScleroderma renal crisis (SRC)Systemic sclerosisThrombotic microangiopathy

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.