Evidence map›Paper›PMID 26711527›Full record

ArticleSchizophrenia research2016

Racial-ethnic disparities in empirically-derived subtypes of subclinical psychosis among a U.S. sample of youths.

Diana Paksarian, Kathleen R Merikangas, Monica E Calkins, Raquel E Gur

Erratum issuedAbstract read
In one paragraph

Article in Schizophrenia research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Persistence of psychosis spectrum symptoms in the Philadelphia Neurodevelopmental Cohort: a prospective two-year follow-up.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2017
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Diana PaksarianGenetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health, 35A Convent Drive, MSC#3720, Bethesda, MD 20892, USA. Electronic address: diana.paksarian@nih.gov.
Kathleen R MerikangasGenetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health, 35A Convent Drive, MSC#3720, Bethesda, MD 20892, USA.
Monica E CalkinsNeuropsychiatry Section, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce St., 10(th) Floor, Gates Bldg., Philadelphia, PA 19104, USA.
Raquel E GurNeuropsychiatry Section, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce St., 10(th) Floor, Gates Bldg., Philadelphia, PA 19104, USA.

Funding

Neurodevelopmental Genomics: Trajectories of Complex PhenotypesRC2MH089983 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RAQUEL E · 2009 to 2011
$14.3M
2/2 Neurodevelopmental Genomics: Trajectories of Complex PhenotypesRC2MH089924 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI HAKONARSON, HAKON · 2009 to 2011
$10.7M
NMDA Receptor Hypofunction in the Amygdala of Schizophrenia PatientsP50MH096891 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI SIEGEL, STEVEN J · 2012 to 2016
$10.6M
Population-Based Epidemiologic ResearchZIAMH002953 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MERIKANGAS, KATHLEEN R · 2016 to 2025
$7.0M
Neurodevelopmental Genomics SupplementZIAMH002931 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MERIKANGAS, KATHLEEN R · 2011 to 2015
$1.2M
A Prospective Study of Endophenotypes in At-Risk Youths and Their SiblingsK08MH079364 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI CALKINS, MONICA E · 2007 to 2011
$750k
Intramural NIH HHS ZIA MH002931NIMH NIH HHS K08 MH079364NIMH NIH HHS K08MH079364NIMH NIH HHS P50 MH096891NIMH NIH HHS P50-MH096891NIMH NIH HHS RC2 MH089924NIMH NIH HHS RC2MH089924NIMH NIH HHS RC2 MH089983NIMH NIH HHS RC2MH089983PHS HHS 1ZIAMH002931-01
6 · The paper itself

Abstract

introductionRacial-ethnic minority status is a consistent risk factor for schizophrenia, with associations extending to bipolar disorder and subthreshold psychotic experiences. However, few epidemiologic studies have been conducted in the U.S., and evidence is inconsistent. Furthermore, no U.S. studies of youths have directly investigated the phenomenological overlap between schizophrenia and bipolar disorder. We aimed to do so at the subthreshold level in the Philadelphia Neurodevelopmental Cohort.

methodsParticipants included 6533 individuals, age 11-21years, from a community healthcare network. Latent class analysis was used to form subtypes of sub-psychosis based on 12 attenuated positive items and 7 mania items without duration criteria. Associations between race-ethnicity (non-Hispanic white, non-Hispanic black, Hispanic, "other") and sub-psychosis subtype were estimated using latent class regression.

resultsFour classes were identified: Sub-positive Only (13.4%), Mania Only (15.5%), Both (9.1%), and Neither (62.0%). Minority participants were generally more likely than non-Hispanic whites to belong to one of the three sub-psychosis classes compared to the Neither class. Associations for Hispanics and non-Hispanic blacks remained after adjustment for age, sex, and maternal education, and restriction to participants without significant physical health conditions. Racial-ethnic disparities were greater in magnitude for the two classes characterized by sub-positive symptoms, Sub-positive Only and Both, than for the Mania Only class. This pattern was statistically significant among non-Hispanic blacks.

conclusionsWe found evidence for racial-ethnic disparities in empirically-derived subtypes of subthreshold psychosis, broadly defined, among U.S. youths. Further research is needed to determine whether these disparities persist to the clinical disorder level in adulthood.

Indexed as

AdolescentBipolar DisorderChildFemaleHumansMalePsychiatric Status Rating ScalesPsychotic DisordersRegression AnalysisUnited StatesYoung AdultEthnicityManiaPsychosisRaceSubthresholdU.S. youths

Identifiers

PMID26711527
PMCPMC4790463

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.