ArticleParasitology research2016
Propolis reduces Leishmania amazonensis-induced inflammation in the liver of BALB/c mice.
Article in Parasitology research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 22 citations in OpenAlex.
- The protective effects of propolis against lipopolysaccharide-induced acute liver injury by modulating serum metabolites and gut flora.Scientific reports · 2025Article
- Ionized alkaline water reduces injury in BALB/c mice infected with Leishmania amazonensis.PloS one · 2023Article
- Promising Anti-Protozoan Activities of Propolis (Bee Glue) as Natural Product: A Review.Acta parasitologica · 2021Review
- The Strong Anti-Kinetoplastid Properties of Bee Propolis: Composition and Identification of the Active Agents and Their Biochemical Targets.Molecules (Basel, Switzerland) · 2020Review
- N-acetyl-L-cysteine reduces Leishmania amazonensis-induced inflammation in BALB/c mice.BMC veterinary research · 2020Article
- Contribution of spinal cord glial cells to L. amazonensis experimental infection-induced pain in BALB/c mice.Journal of neuroinflammation · 2019Article
- Pharmacokinetics of neutron-irradiated meglumine antimoniate inThe journal of venomous animals and toxins including tropical diseases · 2019Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Experimental models of mouse paw infection with L. amazonensis show an induction of a strong inflammatory response in the skin, and parasitic migration may occur to secondary organs with consequent tissue injury. There are few studies focusing on the resolution of damage in secondary organs caused by Leishmania species-related cutaneous leishmaniasis. We investigated the propolis treatment effect on liver inflammation induced by Leishmania amazonensis infection in the mouse paw. BALB/c mice were infected in the hind paw with L. amazonensis (10(7)) promastigote forms. After 15 days, animals were treated daily with propolis (5 mg/kg), Glucantime (10 mg/kg), or with propolis plus Glucantime combined. After 60 days, mice were euthanized and livers were collected for inflammatory process analysis. Liver microscopic analysis showed that propolis reduced the inflammatory process compared to untreated infected control. There was a decrease of liver myeloperoxidase and N-acetyl-β-glucosaminidase activity levels, collagen fiber deposition, pro-inflammatory cytokine production, and plasma aspartate transaminase and alanine transaminase levels. Furthermore, propolis treatment enhanced anti-inflammatory cytokine levels and reversed hepatosplenomegaly. Our data demonstrated that daily low doses of Brazilian propolis reduced the secondary chronic inflammatory process in the liver caused by L. amazonensis subcutaneous infection in a susceptible mice strain.
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Registered trials
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