ArticleJournal of industrial microbiology & biotechnology2016
Enhanced succinic acid productivity by expression of mgtCB gene in Escherichia coli mutant.
Article in Journal of industrial microbiology & biotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 18 citations in OpenAlex.
- High-level succinic acid production by overexpressing a magnesium transporter inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Development of highly efficient and specific base editors in Actinobacillus succinogenes for enhancing succinic acid production.Biotechnology for biofuels and bioproducts · 2023Article
- Hydrolysis of lignocellulose to succinic acid: a review of treatment methods and succinic acid applications.Biotechnology for biofuels and bioproducts · 2023Review
- A novel riboregulator switch system of gene expression for enhanced microbial production of succinic acid.Journal of industrial microbiology & biotechnology · 2018Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, a novel engineering Escherichia coli strain (CBMG111) with the expression of mgtCB gene was constructed for the enhanced fermentative production of succinic acid by utilizing the synergetic effect of mgtC gene to improve the growth of strains at the environment of low Mg(2+) concentration and mgtB to enhance the transport of Mg(2+) into cells. After the effect of the expression of the individual genes (mgtA, mgtB, mgtC) on the growth of E. coli was clarified, the fermentative production of succinic acid by CBMG111 was studied with the low-price mixture of Mg(OH)2 and NH3·H2O as the alkaline neutralizer and the biomass hydrolysates as the carbon sources, which demonstrated that the expression of mgtCB gene can significantly increase the productivity of succinic acid (2.97 g L(-1) h(-1)) compared with that by using the engineering strain with the overexpression of mgtA gene.
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