ArticleCell reports2015
An Amacrine Cell Circuit for Signaling Steady Illumination in the Retina.
Article in Cell reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 77 citations in OpenAlex.
- The extreme diversity of retinal amacrine cells has deep evolutionary roots.Science advances · 2026Article
- Filter, Detector, Predictor: The expanding repertoire of retinal computation in vertebrates.Vision research · 2026Review
- The Extreme Diversity Of Retinal Amacrine Cells Has Deep Evolutionary Roots.bioRxiv : the preprint server for biology · 2026Article
- The mysterious middlemen making your vision pop: understanding the function of amacrine cells.The Journal of physiology · 2025Review
- Nitric oxide modulates contrast suppression in a subset of mouse retinal ganglion cells.eLife · 2025Article
- Cholecystokinin receptor type A are involved in the circadian rhythm of the mouse retina.Heliyon · 2024Article
- A presynaptic source drives differing levels of surround suppression in two mouse retinal ganglion cell types.Nature communications · 2024Article
- Modular interneuron circuits control motion sensitivity in the mouse retina.Nature communications · 2023Article
- Thrombospondin-1 proteomimetic polymers exhibit anti-angiogenic activity in a neovascular age-related macular degeneration mouse model.Science advances · 2023Article
- A sign-inverted receptive field of inhibitory interneurons provides a pathway for ON-OFF interactions in the retina.Nature communications · 2023Article
- Spatial organization of the mouse retina at single cell resolution by MERFISH.Nature communications · 2023Article
- Spike desensitisation as a mechanism for high-contrast selectivity in retinal ganglion cells.Frontiers in cellular neuroscience · 2023Article
- Unified classification of mouse retinal ganglion cells using function, morphology, and gene expression.Cell reports · 2022Article
- Article
- Retinal patterns and the cellular repertoire of neuropsin (Opn5) retinal ganglion cells.The Journal of comparative neurology · 2022Article
- Distinct inhibitory pathways control velocity and directional tuning in the mouse retina.Current biology : CB · 2022Article
- Structure and function of the gap junctional network of photoreceptive ganglion cells.Visual neuroscience · 2021Article
- Identification of retinal ganglion cell types and brain nuclei expressing the transcription factor Brn3c/Pou4f3 using a Cre recombinase knock-in allele.The Journal of comparative neurology · 2021Article
- Nonlinear Spatial Integration Underlies the Diversity of Retinal Ganglion Cell Responses to Natural Images.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Photoreceptive Ganglion Cells Drive Circuits for Local Inhibition in the Mouse Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Decades of research have focused on the circuit connectivity between retinal neurons, but only a handful of amacrine cells have been described functionally and placed in the context of a specific retinal circuit. Here, we identify a circuit where inhibition from a specific amacrine cell plays a vital role in shaping the feature selectivity of a postsynaptic ganglion cell. We record from transgenically labeled CRH-1 amacrine cells and identify a postsynaptic target for CRH-1 amacrine cell inhibition in an atypical retinal ganglion cell (RGC) in mouse retina, the Suppressed-by-Contrast (SbC) RGC. Unlike other RGC types, SbC RGCs spike tonically in steady illumination and are suppressed by both increases and decreases in illumination. Inhibition from GABAergic CRH-1 amacrine cells shapes this unique contrast response profile to positive contrast. We show the existence and impact of this circuit, with both paired recordings and cell-type-specific ablation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.