Evidence map›Paper›PMID 26711243›Full record

ArticleClinical and experimental nephrology2016

Decreases in plasma MMP-2/TIMP-2 and MMP-9/TIMP-1 ratios in uremic patients during hemodialysis.

Li-Che Lu, Chung-Wei Yang, Wen-Yeh Hsieh, Wan-Hsuan Chuang, Yi-Chang Lin, Chih-Sheng Lin

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Article in Clinical and experimental nephrology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

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0cells of the map it votes in
10citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Li-Che LuDepartment of Biological Science and Technology, National Chiao Tung University, No. 75 Bo-Ai Street, Hsinchu, Taiwan.
Chung-Wei YangDepartment of Biological Science and Technology, National Chiao Tung University, No. 75 Bo-Ai Street, Hsinchu, Taiwan.
Wen-Yeh HsiehDivision of Chest Medicine, Department of Internal Medicine, Mackay Memorial Hospital, Hsinchu, Taiwan.
Wan-Hsuan ChuangDepartment of Biological Science and Technology, National Chiao Tung University, No. 75 Bo-Ai Street, Hsinchu, Taiwan.
Yi-Chang LinDepartment of Biological Science and Technology, National Chiao Tung University, No. 75 Bo-Ai Street, Hsinchu, Taiwan.
Chih-Sheng LinDepartment of Biological Science and Technology, National Chiao Tung University, No. 75 Bo-Ai Street, Hsinchu, Taiwan. lincs@mail.nctu.edu.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMatrix metalloproteinases (MMPs) and their endogenous tissue inhibitors (TIMPs) play important roles in the pathophysiology of renal diseases. Imbalanced MMPs/TIMPs are implicated in the vascular alterations of uremic patients on hemodialysis (HD). We have investigated the plasma levels of MMP-2, MMP-9, TIMP-1 and TIMP-2 in uremic patients and the effects of a course of HD on the changes in these factors.

methodsThere were 382 uremic patients on regular HD treatment and 50 healthy controls enrolled in this study. The plasma MMP-2 and MMP-9 levels were detected by gelatin zymography, and TIMP-1 and TIMP-2 concentrations were determined by ELISA assay.

resultsSignificantly higher plasma MMP-2 and MMP-9 and decreased TIMP-1 in the uremic patients were detected compared with those in the controls. Therefore, there were markedly higher MMP-2/TIMP-2 and MMP-9/TIMP-1 ratios in the uremic patients. In the course of a single HD session, the plasma MMP-2 level was significantly decreased from pre-HD to post-HD. TIMP-1 concentration was significantly increased from pre-HD to post-HD. Although the HD session did not have a significant effect on the levels of plasma MMP-9 and TIMP-2, both plasma MMP-2/TIMP-2 and MMP-9/TIMP-1 ratios were significantly decreased from pre-HD to post-HD levels.

conclusionHD session could decrease MMP-2 and increase TIMP-1 level in the circulation of uremic patients. The physiological significance of reduced MMPs/TIMPs ratio due to a single HD session is required to further validate.

Indexed as

Renal DialysisAdultAgedAged, 80 and overFemaleHumansMaleMatrix Metalloproteinase 2Matrix Metalloproteinase 9Middle AgedTissue Inhibitor of Metalloproteinase-1Tissue Inhibitor of Metalloproteinase-2UremiaMatrix Metalloproteinase 2Matrix Metalloproteinase 9MMP2 protein, humanMMP9 protein, humanTIMP1 protein, humanTIMP2 protein, humanTissue Inhibitor of Metalloproteinase-1Tissue Inhibitor of Metalloproteinase-2HemodialysisMatrix metalloproteinaseTissue inhibitor of matrix metalloproteinaseUremic patient

Identifiers

PMID26711243

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.