Evidence map›Paper›PMID 26711100›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2016

Myocardial blood flow: Putting it into clinical perspective.

Thomas Hellmut Schindler

Abstract read
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In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Trial
  2. Article
  3. Prognostic value of combined coronary angiography-derived IMR and myocardial perfusion imaging by CZT SPECT in INOCA.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  4. Article
  5. Article
  6. The diagnostic value of SPECT CZT quantitative myocardial blood flow in high-risk patients.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
  7. Article
  8. Effects of two patient-specific dosing protocols on measurement of myocardial blood flow with 3DEuropean journal of nuclear medicine and molecular imaging · 2021
    Article
  9. Revival of an old stressor: Dobutamine-stimulation for PET myocardial perfusion imaging in patients with end-stage liver disease?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020
    Article
  10. Relative disagreement among different software packages in PET-flow quantitation: An appeal for consistency.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020
    Article
  11. Moving into the next era of PET myocardial perfusion imaging: introduction of novelThe international journal of cardiovascular imaging · 2019
    Review
  12. Article
  13. Article
  14. Role of myocardial perfusion scintigraphy in octogenarians: Time for reappraisal?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018
    Article
  15. Protection of coronary circulation: Evaluation by PET perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Thomas Hellmut SchindlerDivision of Nuclear Medicine, Cardiovascular Nuclear Medicine, Department of Radiology and Radiological Science SOM, Johns Hopkins University School of Medicine, JHOC 3225, 601 N. Caroline Street, Baltimore, MD, 21287, USA. tschind3@jhmi.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, positron emission tomography/computed tomography (PET/CT)-determined myocardial perfusion in conjunction with myocardial blood flow (MBF) quantification in mL·g(-1)·min(-1) has emerged from mere research application to initial clinical use in the detection and characterization of the coronary artery disease (CAD) process. The concurrent evaluation of MBF during vasomotor stress and at rest with the resulting myocardial flow reserve (MFR = MBF during stress/MBF at rest) expands the scope of conventional myocardial perfusion imaging not only to the detection of the most advanced and culprit CAD, as evidenced by the stress-related regional myocardial perfusion defect, but also to the less severe or intermediate stenosis in patients with multivessel CAD. Due to the non-specific nature of the hyperemic MBF and MFR, the interpretation of hyperemic flow increases with PET/CT necessitates an appropriate placement in the context with microvascular function, wall motion analysis, and eventually underlying coronary morphology in CAD patients. This review aims to provide a comprehensive overview of various diagnostic scenarios of PET/CT-determined myocardial perfusion and flow quantification in the detection and characterization of clinically manifest CAD.

Indexed as

Blood Flow VelocityCoronary CirculationCoronary Artery DiseaseEvidence-Based MedicineExercise TestHumansMyocardial Perfusion ImagingPositron Emission Tomography Computed TomographyReproducibility of ResultsSensitivity and SpecificityCADleft ventricular wall motionmultivessel diseasemyocardial blood flowmyocardial flow reservemyocardial ischemiapositron emission tomography

Identifiers

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.