Evidence map›Paper›PMID 26710978›Full record

ArticleDrug and alcohol dependence2016

The dopamine D3 receptor antagonist, SR 21502, facilitates extinction of cocaine conditioned place preference.

E Galaj, J Haynes, R Nisanov, S Ananthan, R Ranaldi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and alcohol dependence, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Dopamine D3 Receptor Modulates Akt/mTOR and ERKInternational journal of molecular sciences · 2023
    Article
  2. Article
  3. Review
  4. Molecular and circuit mechanisms regulating cocaine memory.Cellular and molecular life sciences : CMLS · 2020
    Review
  5. Article
  6. Newly Developed Dopamine DThe Journal of pharmacology and experimental therapeutics · 2019
    Article
  7. Article
  8. Making Sense of: Sensitization in Schizophrenia.The international journal of neuropsychopharmacology · 2017
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

E GalajCUNY, The Graduate Center, United States.
J HaynesDepartment of Psychology, Queens College of the City University of New York, United States.
R NisanovCUNY, The Graduate Center, United States.
S AnanthanDepartment of Chemistry, Drug Discovery Division, Southern Research Institute, United States.
R RanaldiCUNY, The Graduate Center, United States; Department of Psychology, Queens College of the City University of New York, United States. Electronic address: Robert.Ranaldi@qc.cuny.edu.
Queens College, CUNY · USThe Graduate Center, CUNY · USSouthern Research Institute · US

Funding

Development of Dopamine D3 Ligands as Medications for Psychostimulant AddictionR01DA024675 · NIDA · SOUTHERN RESEARCH INSTITUTE · PI ANANTHAN, SUBRAMANIAM · 2009 to 2011
$1.4M
NIDA NIH HHS R01 DA024675NIDA NIH HHS R01DA024675
6 · The paper itself

Abstract

backgroundPharmacotherapeutic agents that could facilitate extinction of cocaine cues would be useful in the treatment of cocaine addiction. We tested whether SR 21502, a selective dopamine (DA) D3 receptor antagonist, can facilitate extinction of cocaine conditioned place preference (CPP) in rats.

methodsIn experiment 1, cocaine (10mg/kg) CPP was first established and then extinguished. During the extinction phase the rats were injected with SR 21502 and placed in the previously cocaine-paired compartment for four sessions and vehicle in the other compartment on four alternating sessions. The rats were then tested again for cocaine CPP. In experiment 2, different groups of rats were trained to associate SR 21502 with one compartment and saline with the other.

resultsIn experiment 1, the animals spent significantly more time in the cocaine-paired compartment after cocaine conditioning than they did before conditioning. Subsequently, the animals treated with SR 21502 during the extinction phase spent significantly less time in the cocaine-paired compartment than the vehicle group. In experiment 2, animals conditioned with SR 21502 preferred neither side of the CPP apparatus, indicating that SR 21502 produced no effects of its own.

conclusionsThese findings suggest that treatment with SR 21502, a DA D3 receptor antagonist, in the presence of cocaine cues can facilitate extinction of cocaine CPP and further suggest that this compound might be an effective cocaine addiction treatment.

Indexed as

AnimalsCocaineConditioning, PsychologicalCuesExtinction, PsychologicalImidazolesMalePyridinesRatsReceptors, Dopamine D3CocaineImidazolesPyridinesReceptors, Dopamine D3SR 21502AddictionCocaineConditioned place preferenceD3 receptor antagonistExtinctionReward

Identifiers

PMID26710978
PMCPMC4724481
OpenAlexW2193294104

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.