ArticleGenome biology and evolution2015
A Comprehensive tRNA Genomic Survey Unravels the Evolutionary History of tRNA Arrays in Prokaryotes.
Article in Genome biology and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 26 citations in OpenAlex.
- Bacteria can maintain rRNA operons solely on plasmids for hundreds of millions of years.Nature communications · 2023Article
- Whole-genome sequence of the filamentous diazotrophic cyanobacteriumFrontiers in microbiology · 2022Article
- Role of a cryptic tRNA gene operon in survival under translational stress.Nucleic acids research · 2021Article
- ComprehensiveMicrobial genomics · 2021Article
- Eukaryotic life without tQCUG: the role of Elongator-dependent tRNA modifications in Dictyostelium discoideum.Nucleic acids research · 2020Article
- The rare lncRNA GOLLD is widespread and structurally conserved amongRNA biology · 2020Article
- Operon-based approach for the inference of rRNA and tRNA evolutionary histories in bacteria.BMC genomics · 2020Article
- GlobalViruses · 2019Article
- Exploring tRNA gene cluster in archaea.Memorias do Instituto Oswaldo Cruz · 2019Article
- Mycobacterium genus and tRNA arrays.Memorias do Instituto Oswaldo Cruz · 2019Article
- Mitochondrial genomes of two diplectanids (Platyhelminthes: Monogenea) expose paraphyly of the order Dactylogyridea and extensive tRNA gene rearrangements.Parasites & vectors · 2018Article
- Genomic diversity and distribution of Bifidobacterium longum subsp. longum across the human lifespan.Scientific reports · 2018Article
- Genome-Wide Analysis Reveals Ancestral Lack of Seventeen Different tRNAs and Clade-Specific Loss of tRNA-CNNs in Archaea.Frontiers in microbiology · 2018Article
- Beyond the Limits: tRNA Array Units inFrontiers in microbiology · 2018Article
- Functionality of tRNAs encoded in a mobile genetic element from an acidophilic bacterium.RNA biology · 2018Article
- Comparative Genome Analysis Provides Insights into Both the Lifestyle ofFrontiers in microbiology · 2017Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Considering the importance of tRNAs in the translation machinery, scant attention has been paid to tRNA array units defined as genomic regions containing at least 20 tRNA genes with a minimal tRNA gene density of two tRNA genes per kilobase. Our analysis of Acidithiobacillus ferrivorans CF27 and Acidithiobacillus ferrooxidans ATCC 23270(T) genomes showed that both display a tRNA array unit with syntenic conservation which mainly contributed to the tRNA gene redundancy in these two organisms. Our investigations into the occurrence and distribution of tRNA array units revealed that 1) this tRNA organization is limited to few phyla and mainly found in Gram-positive bacteria; and 2) the presence of tRNA arrays favors the redundancy of tRNA genes, in particular those encoding the core tRNA isoacceptors. Finally, comparative array organization revealed that tRNA arrays were acquired through horizontal gene transfer (from Firmicutes or unknown donor), before being subjected to tRNA rearrangements, deletions, and duplications. In Bacilli, the most parsimonious evolutionary history involved two common ancestors and the acquisition of their arrays arose late in evolution, in the genera branches. Functional roles of the array units in organism lifestyle, selective genetic advantage and translation efficiency, as well as the evolutionary advantages of organisms harboring them were proposed. Our study offers new insight into the structural organization and evolution of tRNA arrays in prokaryotic organisms.
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