Evidence map›Paper›PMID 26710757›Full record

SynthesisJournal of endocrinological investigation2016

Polymorphisms of CASR gene increase the risk of primary hyperparathyroidism.

X-M Wang, Y-W Wu, Z-J Li, X-H Zhao, S-M Lv, X-H Wang

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Journal of endocrinological investigation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. A Pilot Study ofBalkan journal of medical genetics : BJMG · 2024
    Article
  3. Article
  4. Epidemiology, Pathophysiology, and Genetics of Primary Hyperparathyroidism.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Review
  5. Observational
  6. Diseases associated with calcium-sensing receptor.Orphanet journal of rare diseases · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

X-M WangDepartment of Nephrology, Shaanxi Provincial People's Hospital, Xi'an, 710068, Shaanxi, China.
Y-W WuSecond Department of Gastroenterology, Shaanxi Provincial People's Hospital, No. 256 West Youyi Road, Xi'an, 710068, Shaanxi, China.
Z-J LiDepartment of Nephrology, Shaanxi Provincial People's Hospital, Xi'an, 710068, Shaanxi, China.
X-H ZhaoDepartment of Nephrology, Shaanxi Provincial People's Hospital, Xi'an, 710068, Shaanxi, China.
S-M LvSecond Department of Gastroenterology, Shaanxi Provincial People's Hospital, No. 256 West Youyi Road, Xi'an, 710068, Shaanxi, China. samei_lv@126.com.
X-H WangDepartment of Nephrology, Shaanxi Provincial People's Hospital, Xi'an, 710068, Shaanxi, China.
Shanxi Medical University · CNShaanxi Provincial People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate correlations between polymorphisms of calcium-sensing receptor (CASR) gene [A986S (rs1081725), R990G (rs1042636) and Q1011E (rs1801726)] and the risk of primary hyperparathyroidism (PHPT) among human population.

methodsRelevant studies were retrieved from online databases using computer-based search strategies, which were then supplemented by manual search strategies. Case-control studies related to our topic were identified based on strict inclusion and exclusion criteria. Statistical analyses were conducted using the Comprehensive Meta-analysis 2.0 (Biostat Inc., Englewood, NJ, USA).

resultsWe retrieved 202 studies from online databases and other sources initially and eventually enrolled six studies into our meta-analysis. These six studies contained a sum of 693 PHPT patients and 1252 healthy controls. Our meta-analysis results showed that single nucleotide polymorphisms (SNPs) of CASR gene A986S (rs1081725) and R990G (rs1042636), but not Q1011E (rs1801726), may increase the risk of PHPT [A986S (rs1081725): allele model: P = 0.013; dominant model: P = 0.044; R990G (rs1042636): allele model: P = 0.023; dominant model: P = 0.026)]. Subgroup analyses based on ethnicity showed that among Asians, A986S (rs1081725) increased the PHPT risk (P = 0.04) under the allele model, but not under the dominant model. Among Caucasians, there was no association between gene frequencies and PHPT under both the allele and dominant model. In Asians, no significant association was observed between R990G (rs1042636) and PHPT risk, but in Caucasians, R990G (rs1042636) significantly increased the incidence of PHPT [R990G (rs1042636): allele model: P = 0.015; dominant model: P = 0.009)].

conclusionOur results indicate that SNPs of CASR gene A986S (rs1081725) and R990G (rs1042636) may increase the risk of PHPT, and the polymorphisms can potentially be used as important biological markers for early diagnosis of PHPT.

Indexed as

Case-Control StudiesHumansHyperparathyroidism, PrimaryPolymerase Chain ReactionPolymorphism, Restriction Fragment LengthPolymorphism, Single NucleotideReceptors, Calcium-SensingRisk FactorsReceptors, Calcium-SensingA986S (rs1081725)Calcium-sensing receptorCASR geneMeta-analysisPolymorphismPrimary hyperparathyroidismQ1011E (rs1801726)R990G (rs1042636)

Identifiers

PMID26710757
OpenAlexW2277217241

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.