ReviewBlood transfusion = Trasfusione del sangue2016
Leucoreduction of blood components: an effective way to increase blood safety?
Review in Blood transfusion = Trasfusione del sangue, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cytomegalovirus seroprevalence among blood donors: a systematic review and meta-analysis.The Journal of international medical research · 2021Pooled it
- Prestorage Leukoreduction of Canine Blood Products: A Critically Appraised Topic.Veterinary sciences · 2026Review
- Molecular Mechanisms of Transfusion-Associated Immunomodulation and Its Impact in the Critically Ill.International journal of molecular sciences · 2025Review
- Pathogen-Reduced Low-Titer Group O Whole Blood for Managing Massive Blood Loss in Prehospital and Early Hospital Settings: An In Vitro Study.Journal of clinical medicine · 2025Article
- Effect of leukoreduction in preventing febrile transfusion reactions.Bioinformation · 2025Article
- Associations of Perioperative Red Blood Cell Transfusion With Outcomes of Kidney Transplantation in Korea Over a 16-Year Period.Journal of Korean medical science · 2023Article
- Investigation of the patients with recurrent acute transfusion reactions: A single tertiary medical centre experience.The Journal of international medical research · 2023Article
- Evaluation of a New Method of Leukocyte Extractions from the Leukoreduction Filter.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2023Article
- Evaluation of leukocyte depletion of packed red blood cell units and impact on clinically observed transfusion reactions.Frontiers in veterinary science · 2023Article
- Transfusion of target antigens to preimmunized recipients: a new mechanism in transfusion-related acute lung injury.Blood advances · 2021Article
- Randomized double-blinded clinical trial on acute transfusion reactions in dogs receiving leukoreduced versus nonleukoreduced packed red blood cells.Journal of veterinary internal medicine · 2021Article
- Effects of transfusion of stored blood in patients with transfusion-dependent thalassemia.American journal of blood research · 2021Article
- The Effects of Pre-Storage Leukoreduction on the Conservation of Bovine Whole Blood in Plastic Bags.Biology · 2020Article
- Neutrophil extracellular traps in stored canine red blood cell units.Journal of veterinary internal medicine · 2020Article
- Plasma Transfusion Products and Contamination with Cellular and Associated Pro-Inflammatory Debris.Journal of the American College of Surgeons · 2019Article
- Platelet-, leucocyte- and red cell-derived microparticles in stored whole blood, with and without leucofiltration, with and without ionising radiation.Blood transfusion = Trasfusione del sangue · 2018Article
- Early predictors of Guillain-Barré syndrome in the life course of women.International journal of epidemiology · 2018Article
- A portable system for processing donated whole blood into high quality components without centrifugation.PloS one · 2018Article
- The accumulation of lipids and proteins during red blood cell storage: the roles of leucoreduction and experimental filtration.Blood transfusion = Trasfusione del sangue · 2017Review
- A Novel Centrifugation Method Using a Cell Salvage Device Offers an Alternative to the Use of Leukocyte-Depleting Filters for Autologous Blood Transfusions.The journal of extra-corporeal technology · 2016Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the past 30 years, it has been demonstrated that removal of white blood cells from blood components is effective in preventing some adverse reactions such as febrile non-haemolytic transfusion reactions, immunisation against human leucocyte antigens and human platelet antigens, and transmission of cytomegalovirus. In this review we discuss indications for leucoreduction and classify them into three categories: evidence-based indications for which the clinical efficacy is proven, indications based on the analysis of observational clinical studies with very consistent results and indications for which the clinical efficacy is partial or unproven.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.