ArticleNeuropsychology2016
Genetic factors moderate everyday physical activity effects on executive functions in aging: Evidence from the Victoria Longitudinal Study.
Article in Neuropsychology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The Factor Structure of Cognitive Functioning in Cognitively Healthy Participants: a Meta-Analysis and Meta-Analysis of Individual Participant Data.Neuropsychology review · 2020Pooled it
- The unity and diversity of executive functions: A systematic review and re-analysis of latent variable studies.Psychological bulletin · 2018Pooled it
- Impact of brain-derived neurotrophic factor genetic polymorphism on cognition: A systematic review.Brain and behavior · 2018Pooled it
- Aerobic exercise improves executive functions in females, but not males, without the BDNF Val66Met polymorphism.Biology of sex differences · 2023Trial
- Menstrual cycle modulates the effect of BDNF Val66Met variant on category learning.Biology of sex differences · 2026Article
- Increased frequency of light physical activity during midlife and old age buffers against cognitive declines.Journal of behavioral medicine · 2024Article
- A longitudinal study of polygenic score and cognitive function decline considering baseline cognitive function, lifestyle behaviors, and diabetes among middle-aged and older US adults.Alzheimer's research & therapy · 2023Article
- Physical activity moderates the association between executive function and functional connectivity in older adults.Aging brain · 2022Article
- Data-driven approaches to executive function performance and structure in aging: Integrating person-centered analyses and machine learning risk prediction.Neuropsychology · 2021Article
- FEASibility testing a randomized controlled trial of an exercise program to improve cognition for T2DM patients (the FEAST trial): A study protocol.Research in nursing & health · 2021Article
- Physical Activity and Trajectory of Cognitive Change in Older Persons: Mayo Clinic Study of Aging.Journal of Alzheimer's disease : JAD · 2021Article
- A Multimodal Risk Network Predicts Executive Function Trajectories in Non-demented Aging.Frontiers in aging neuroscience · 2021Article
- Body mass index predicts cognitive aging trajectories selectively for females: Evidence from the Victoria Longitudinal Study.Neuropsychology · 2020Article
- TheBrain sciences · 2020Review
- Executive function performance and change in aging is predicted by apolipoprotein E, intensified by catechol-O-methyltransferase and brain-derived neurotrophic factor, and moderated by age and lifestyle.Neurobiology of aging · 2017Article
- Interaction betweenFrontiers in human neuroscience · 2017Article
- Cognitive activity mediates the association between social activity and cognitive performance: A longitudinal study.Psychology and aging · 2016Article
- Article
- Physical Exercise and Longitudinal Trajectories in Alzheimer Disease Biomarkers and Cognitive Functioning.Alzheimer disease and associated disordersArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveEveryday physical activity (EPA) is an important modifiable contributor to age-related variability in executive functioning (EF). However, its role may be moderated by nonmodifiable genetic factors. We tested independent and interactive effects of brain-derived neurotrophic factor (BDNF rs6265) and insulin degrading enzyme (IDE rs6583817) on EF and EPA-EF relationships.
methodThe sample consisted of genotyped older adults (N = 577; M age = 70.47 years) over 3 waves (∼9 years) of the Victoria Longitudinal Study. Analyses included (a) confirmatory factor analysis establishing a single latent EF factor from 4 standard EF tasks, (b) latent growth modeling over a 40-year band of aging (ages 53 to 95), and (c) structural regression to investigate the independent and interactive effects of BDNF, IDE, and EPA.
resultsFirst, higher levels of EPA were associated with better EF performance at the centering age (75 years) and less EF decline. Second, IDE G+ (protective) carriers exhibited better EF performance at Age 75 than their G- (nonprotective) peers. Third, within the IDE G+ carrier group, those with higher EPA exhibited better EF performance and slower decline over time than those with lower EPA. Fourth, for the BDNF homozygote Val group, higher EPA was associated with better EF performance and more gradual EF change; however, this beneficial effect was not seen for Met carriers.
conclusionThe effect of modifiable physical health factors on EF is moderated by biological mechanisms associated with risk-protection genetic polymorphisms.
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