ArticleThe Journal of cell biology1989
Yeast proteins that recognize nuclear localization sequences.
Article in The Journal of cell biology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 98 citations in OpenAlex.
- Review
- Inhibition of HIV-1 integrase nuclear import and replication by a peptide bearing integrase putative nuclear localization signal.Retrovirology · 2009Article
- A novel in vivo assay reveals inhibition of ribosomal nuclear export in ran-cycle and nucleoporin mutants.The Journal of cell biology · 1999Article
- Characterization of a Drosophila phosphorylation-dependent nuclear-localization-signal-binding protein.The Biochemical journal · 1997Article
- A role for HDJ-2/HSDJ in correcting subnuclear trafficking, transactivation, and transrepression defects of a glucocorticoid receptor zinc finger mutant.Molecular biology of the cell · 1997Article
- Binding of the peroxisomal targeting sequence SKL is specified by a low-affinity site in castor bean glyoxysomal membranes. A domain next to the SKL binds to a high-affinity site.Plant physiology · 1997Article
- Identification of a cytoplasm to vacuole targeting determinant in aminopeptidase I.The Journal of cell biology · 1996Article
- The yeast nuclear import receptor is required for mitosis.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Adenoviral E1B-55kDa protein inhibits yeast mRNA export and perturbs nuclear structure.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- The serum response factor nuclear localization signal: general implications for cyclic AMP-dependent protein kinase activity in control of nuclear translocation.Molecular and cellular biology · 1995Article
- Differential roles of heat shock protein 70 in the in vitro nuclear import of glucocorticoid receptor and simian virus 40 large tumor antigen.Molecular and cellular biology · 1994Article
- Nucleocytoplasmic transport.The Biochemical journal · 1994Review
- The lysosomal proenzyme receptor that binds procathepsin L to microsomal membranes at pH 5 is a 43-kDa integral membrane protein.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Reconstitution of nuclear protein transport with semi-intact yeast cells.The Journal of cell biology · 1993Article
- Extragenic suppressors of mutations in the cytoplasmic C terminus of SEC63 define five genes in Saccharomyces cerevisiae.Genetics · 1993Article
- A cytoplasmically anchored nuclear protein interferes specifically with the import of nuclear proteins but not U1 snRNA.The Journal of cell biology · 1993Article
- NUP2, a novel yeast nucleoporin, has functional overlap with other proteins of the nuclear pore complex.Molecular biology of the cell · 1993Article
- Role of nuclear pore complex in simian virus 40 nuclear targeting.Journal of virology · 1993Article
- Antibodies against 70-kD heat shock cognate protein inhibit mediated nuclear import of karyophilic proteins.The Journal of cell biology · 1992Article
- Enhancement of polyhedrin nuclear localization during baculovirus infection.Journal of virology · 1992Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
A variety of peptides can mediate the localization of proteins to the nucleus. We have identified yeast proteins of 70 and 59 kD that bind to nuclear localization peptides of SV-40 T antigen, Xenopus nucleoplasmin, and the yeast proteins Ga14 and histone H2B. These proteins are assayed by the binding of peptide-albumin conjugates to proteins immobilized on nitrocellulose filters. These binding proteins fractionate with nuclei and are extractable with salt but not detergent. Radiolabeled peptide-albumin conjugates also bind to isolated nuclei; the binding is saturable and can be extracted with salt. Different nuclear localization peptides compete with each other, implying that a single class of proteins is responsible for their recognition. The 70- and 59-kD proteins have the properties expected for a receptor that would act to direct proteins to the nucleus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.